儿童和年轻人克罗恩病的对比增强超声:定量度量相关性和MRI疾病严重程度相关

IF 2.1 3区 医学 Q2 PEDIATRICS
Jonathan R Dillman, Adam F Prasanphanich, Katherine N Epstein, Alexander J Towbin, Andrew T Trout
{"title":"儿童和年轻人克罗恩病的对比增强超声:定量度量相关性和MRI疾病严重程度相关","authors":"Jonathan R Dillman, Adam F Prasanphanich, Katherine N Epstein, Alexander J Towbin, Andrew T Trout","doi":"10.1007/s00247-025-06203-8","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>There is a paucity of data comparing contrast-enhanced ultrasound (CEUS) to MR enterography in children and young adults with Crohn's disease.</p><p><strong>Objective: </strong>To measure correlations across CEUS quantitative metrics in children and young adults with Crohn's disease, and to evaluate if these metrics are associated with MRI features of disease activity.</p><p><strong>Materials and methods: </strong>Patients <21 years old with Crohn's disease affecting the terminal ileum who underwent clinically-indicated MR enterography were recruited between 2021 and 2024. Research CEUS of the terminal ileum was performed using sulfur hexafluoride lipid-type A microspheres, and images were analyzed using VueBox (Bracco Group). MRI exams were independently reviewed by three radiologists to document features of disease activity. Pearson's correlation (r) was used to measure associations across nine CEUS quantitative metrics and between CEUS metrics and mean or consensus MRI features.</p><p><strong>Results: </strong>Twenty-five participants, 13 (52%) male, with a mean age of 16.5 years (range, 13-20 years) were included. The mean terminal ileal maximum bowel wall thickness at MRI was 7.5 mm±1.8 mm. The mean sMaRIA score was 3.4±0.8, consistent with severely active disease. CEUS quantitative measurements were highly variable across participants. The mean rise time was 7.0±2.7 s, while the mean peak enhancement was 3,282±3,754 a.u. Twelve of 36 (36%) CEUS quantitative metric bivariate comparisons were highly collinear with r>0.8 (P<0.0001). There were significant positive correlations between CEUS rise time and MRI maximum bowel wall thickness (r=0.40; P=0.046), visual analog scale assessment of overall inflammation (r=0.43; P=0.032), and postcontrast enhancement ratio (r=0.47; P=0.018); there were no other significant correlations between CEUS metrics and MRI measures of inflammation.</p><p><strong>Conclusion: </strong>CEUS quantitative measurements are highly variable across patients with Crohn's disease, with multiple metrics being highly correlated with one another. CEUS rise time correlates with MRI features of disease activity.</p>","PeriodicalId":19755,"journal":{"name":"Pediatric Radiology","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Contrast-enhanced ultrasound of Crohn's disease in children and young adults: quantitative metric correlations and MRI disease severity associations.\",\"authors\":\"Jonathan R Dillman, Adam F Prasanphanich, Katherine N Epstein, Alexander J Towbin, Andrew T Trout\",\"doi\":\"10.1007/s00247-025-06203-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>There is a paucity of data comparing contrast-enhanced ultrasound (CEUS) to MR enterography in children and young adults with Crohn's disease.</p><p><strong>Objective: </strong>To measure correlations across CEUS quantitative metrics in children and young adults with Crohn's disease, and to evaluate if these metrics are associated with MRI features of disease activity.</p><p><strong>Materials and methods: </strong>Patients <21 years old with Crohn's disease affecting the terminal ileum who underwent clinically-indicated MR enterography were recruited between 2021 and 2024. Research CEUS of the terminal ileum was performed using sulfur hexafluoride lipid-type A microspheres, and images were analyzed using VueBox (Bracco Group). MRI exams were independently reviewed by three radiologists to document features of disease activity. Pearson's correlation (r) was used to measure associations across nine CEUS quantitative metrics and between CEUS metrics and mean or consensus MRI features.</p><p><strong>Results: </strong>Twenty-five participants, 13 (52%) male, with a mean age of 16.5 years (range, 13-20 years) were included. The mean terminal ileal maximum bowel wall thickness at MRI was 7.5 mm±1.8 mm. The mean sMaRIA score was 3.4±0.8, consistent with severely active disease. CEUS quantitative measurements were highly variable across participants. The mean rise time was 7.0±2.7 s, while the mean peak enhancement was 3,282±3,754 a.u. Twelve of 36 (36%) CEUS quantitative metric bivariate comparisons were highly collinear with r>0.8 (P<0.0001). There were significant positive correlations between CEUS rise time and MRI maximum bowel wall thickness (r=0.40; P=0.046), visual analog scale assessment of overall inflammation (r=0.43; P=0.032), and postcontrast enhancement ratio (r=0.47; P=0.018); there were no other significant correlations between CEUS metrics and MRI measures of inflammation.</p><p><strong>Conclusion: </strong>CEUS quantitative measurements are highly variable across patients with Crohn's disease, with multiple metrics being highly correlated with one another. CEUS rise time correlates with MRI features of disease activity.</p>\",\"PeriodicalId\":19755,\"journal\":{\"name\":\"Pediatric Radiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-03-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Radiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00247-025-06203-8\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Radiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00247-025-06203-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

摘要

背景:比较对比增强超声(CEUS)和MR肠造影在儿童和青年克罗恩病中的应用的数据缺乏。目的:测量克罗恩病儿童和年轻人CEUS定量指标的相关性,并评估这些指标是否与疾病活动性的MRI特征相关。材料与方法:患者结果:纳入25例患者,男性13例(52%),平均年龄16.5岁(范围13-20岁)。MRI显示回肠末端平均最大肠壁厚度为7.5 mm±1.8 mm。sMaRIA平均评分为3.4±0.8,与严重活动性疾病一致。超声造影定量测量结果在参与者之间差异很大。平均上升时间为7.0±2.7 s,平均峰值增强为3,282±3,754 a.u。36个CEUS定量指标双变量比较中有12个(36%)与r >.8高度共线(p结论:CEUS定量测量在克罗恩病患者中变化很大,多个指标彼此高度相关。超声造影上升时间与疾病活动性的MRI特征相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Contrast-enhanced ultrasound of Crohn's disease in children and young adults: quantitative metric correlations and MRI disease severity associations.

Background: There is a paucity of data comparing contrast-enhanced ultrasound (CEUS) to MR enterography in children and young adults with Crohn's disease.

Objective: To measure correlations across CEUS quantitative metrics in children and young adults with Crohn's disease, and to evaluate if these metrics are associated with MRI features of disease activity.

Materials and methods: Patients <21 years old with Crohn's disease affecting the terminal ileum who underwent clinically-indicated MR enterography were recruited between 2021 and 2024. Research CEUS of the terminal ileum was performed using sulfur hexafluoride lipid-type A microspheres, and images were analyzed using VueBox (Bracco Group). MRI exams were independently reviewed by three radiologists to document features of disease activity. Pearson's correlation (r) was used to measure associations across nine CEUS quantitative metrics and between CEUS metrics and mean or consensus MRI features.

Results: Twenty-five participants, 13 (52%) male, with a mean age of 16.5 years (range, 13-20 years) were included. The mean terminal ileal maximum bowel wall thickness at MRI was 7.5 mm±1.8 mm. The mean sMaRIA score was 3.4±0.8, consistent with severely active disease. CEUS quantitative measurements were highly variable across participants. The mean rise time was 7.0±2.7 s, while the mean peak enhancement was 3,282±3,754 a.u. Twelve of 36 (36%) CEUS quantitative metric bivariate comparisons were highly collinear with r>0.8 (P<0.0001). There were significant positive correlations between CEUS rise time and MRI maximum bowel wall thickness (r=0.40; P=0.046), visual analog scale assessment of overall inflammation (r=0.43; P=0.032), and postcontrast enhancement ratio (r=0.47; P=0.018); there were no other significant correlations between CEUS metrics and MRI measures of inflammation.

Conclusion: CEUS quantitative measurements are highly variable across patients with Crohn's disease, with multiple metrics being highly correlated with one another. CEUS rise time correlates with MRI features of disease activity.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Pediatric Radiology
Pediatric Radiology 医学-核医学
CiteScore
4.40
自引率
17.40%
发文量
300
审稿时长
3-6 weeks
期刊介绍: Official Journal of the European Society of Pediatric Radiology, the Society for Pediatric Radiology and the Asian and Oceanic Society for Pediatric Radiology Pediatric Radiology informs its readers of new findings and progress in all areas of pediatric imaging and in related fields. This is achieved by a blend of original papers, complemented by reviews that set out the present state of knowledge in a particular area of the specialty or summarize specific topics in which discussion has led to clear conclusions. Advances in technology, methodology, apparatus and auxiliary equipment are presented, and modifications of standard techniques are described. Manuscripts submitted for publication must contain a statement to the effect that all human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in an appropriate version of the 1964 Declaration of Helsinki. It should also be stated clearly in the text that all persons gave their informed consent prior to their inclusion in the study. Details that might disclose the identity of the subjects under study should be omitted.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信