超声多普勒肾脏搏动指数是单功能肾脏儿童动脉僵化的预测指标。

IF 1.3 Q3 UROLOGY & NEPHROLOGY
Seçil Conkar Tunçay, Gonca Koç, Gülden Hakverdi
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引用次数: 0

摘要

孤立功能肾(SFK)患者有肾小球过滤、高血压、蛋白尿和肾功能受损,导致微血管粥样硬化异常。这种情况导致动脉硬化增加。在这项研究中,我们旨在探讨无创肾多普勒超声血流动力学参数在显示SFK患儿动脉僵硬度方面的作用。方法:研究对象为59例6-18岁确诊为SFK的儿童。记录人口统计学、生物化学、人体测量学和血压数据。评估肾多普勒超声血流动力学参数肾阻力指数(RRI)、肾脉动指数(RPI)、颈动脉-股动脉脉波速度(cfPWV)、中心增强指数(cAIx)和颈动脉内膜中膜厚度(cIMT)。结果:检出获得性SFK 18例(30.5%),先天性SFK 41例(64.5%)。先天性SFK患儿的中枢增强指数高于后天性SFK患儿(p = 0.038)。获得性SFK患者的CkiD-eGFR-SCr-CysC较低(p = 0.011)。获得性SFK患儿的LDL胆固醇水平较高(p = 0.018)。我们发现RPI和cfPWV之间存在显著的相关性,相关系数(r)为0.321,p值为0.013,具有统计学意义。结论:先天性SFK与微血管粥样硬化负担增加有关。肾多普勒超声RPI评估可能是一种非侵入性的方法,以确定动脉僵硬。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ultrasound Doppler renal pulsatility index is a predictive marker of arterial stiffness in children with solitary functioning kidney.

Introduction: Patients with solitary functioning kidney (SFK) have glomerular hyperfiltration, hypertension, proteinuria and impaired renal function resulting in microvascular atherosclerotic abnormalities. This condition leads to an increase in arterial stiffness. In this study, we aimed to investigate the usefulness of non-invasive renal Doppler ultrasonography hemodynamic parameters in demonstrating arterial stiffness in pediatric patients with SFK.

Methods: The study included 59 children aged 6-18 years who were diagnosed with SFK. Demographic, biochemical, anthropometric, and blood pressure data were recorded. The renal Doppler ultrasound hemodynamic parameters renal resistive index (RRI), renal pulsatility index (RPI), carotid-femoral pulse wave velocity (cfPWV), central augmentation index (cAIx) and carotid intima media thickness (cIMT) were evaluated.

Results: Eighteen (30.5%) cases with acquired SFK and 41 (64.5%) cases with congenital SFK were detected. Central augmentation indices were higher in children with congenital SFK than in children with acquired SFK (p = 0.038). CkiD-eGFR-SCr-CysC was lower in patients with acquired SFK (p = 0.011). LDL cholesterol levels were higher in children with acquired SFK (p = 0.018). We found a significant correlation between RPI and cfPWV with a correlation coefficient (r) of 0.321 and a statistically significant p-value of 0.013.

Conclusions: Congenital SFK is associated with increased microvascular atherosclerotic burden. RPI assessment with renal Doppler ultrasound may be a non-invasive method to identify arterial stiffness.

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来源期刊
CiteScore
2.20
自引率
16.70%
发文量
208
审稿时长
16 weeks
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