母亲母乳中有毒金属和微量元素及其对婴儿健康风险的评估：伊朗西北部阿尔达比勒的一项横断面研究。

IF 3.9 3区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food and Chemical Toxicology Pub Date : 2025-03-12 DOI:10.1016/j.fct.2025.115389

Abdollah Dargahi , Hamed Zandian , Fateme Samiee , Shahla Farzipour , Negin Sheikhmemari , Salva Kazemipour-Khabbazi

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引用次数: 0

摘要

这项研究旨在评估对婴儿的潜在健康风险，并测量居住在伊朗阿达比尔的母亲母乳中重金属物质的浓度。该研究本质上是描述性和横断面性的。阿达比尔市的十个保健中心被选为研究对象。参与研究的母亲年龄从19岁到39岁不等，母乳样本采集自产后1到12个月的母亲。一份包含25个项目的调查问卷用于评估参与者在环境和饮食中接触重金属的情况。数据分析采用非参数Mann-Whitney U检验，p值大于0.05。母乳喂养母亲的平均体重指数（BMI）为26.26±3.73。峰值回收率范围为92% ~ 106%，在ICP-MS范围内表现可靠。常规样品分析的检出限为0.001 μg/L。计算婴儿每日铅（Pb）、砷（As）、铬（Cr）的摄入量。结果表明，母乳中铜（Cu）的平均浓度最高，为803.94 μg/L，镉（Cd）的平均浓度最低，为1.87 μg/L。钾(K)的平均浓度最高，为490.49 mg/L，钼（Mo）的平均浓度最低，为0.8 μg/L。母乳喂养小鼠的平均日Pb、As和Cr摄入量分别为3.39、0.799和3.47 μg/kg-bw/d。结果证实，从阿达比尔的哺乳期母亲收集的每个牛奶样本中都存在汞（Hg）、砷和铅，这表明婴儿可能接触到高浓度的有毒重金属。

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Assessment of toxic metals and trace elements in breast milk of mothers and their health risks to infants: A cross-sectional study in Ardabil, Northwest Iran

This research aimed to assess the potential health risks for infants and measure the concentrations of heavy metal substances in the breast milk of mothers residing in Ardabil, Iran. The study was descriptive and cross-sectional in nature. Ten health centers in Ardabil City were selected for the research. The ages of participating mothers ranged from 19 to 39 years, and breast milk samples were collected from those who were 1–12 months postpartum. A 25-item questionnaire was used to evaluate the participants' exposure to heavy metals in their environment and diet. Data analysis was performed using the non-parametric Mann-Whitney U test, resulting in a p-value greater than 0.05. The average body mass index (BMI) of breastfeeding mothers was 26.26 ± 3.73. Spike recovery values ranged from 92 % to 106 %, indicating reliable performance within the ICP-MS range. The limit of detection (LOD) during routine sample analysis was 0.001 μg/L. The daily intake (DI) of lead (Pb), arsenic (As), and chromium (Cr) for infants was calculated. According to the findings, copper (Cu) had the highest average concentration in breast milk at 803.94 μg/L, while cadmium (Cd) had the lowest at 1.87 μg/L. Additionally, potassium (K) exhibited the highest average concentration at 490.49 mg/L, whereas molybdenum (Mo) had the lowest at 0.8 μg/L. The average daily intake of Pb, As, and Cr through breastfeeding was measured at 3.39, 0.799, and 3.47 μg/kg-bw/day, respectively. The results confirmed the presence of mercury (Hg), As, and Pb in every milk sample collected from lactating mothers in Ardabil, indicating potential exposure of infants to elevated levels of toxic heavy metals.

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来源期刊

Food and Chemical Toxicology 工程技术-毒理学

CiteScore

10.90

自引率

4.70%

发文量

651

审稿时长

31 days

期刊介绍： Food and Chemical Toxicology (FCT), an internationally renowned journal, that publishes original research articles and reviews on toxic effects, in animals and humans, of natural or synthetic chemicals occurring in the human environment with particular emphasis on food, drugs, and chemicals, including agricultural and industrial safety, and consumer product safety. Areas such as safety evaluation of novel foods and ingredients, biotechnologically-derived products, and nanomaterials are included in the scope of the journal. FCT also encourages submission of papers on inter-relationships between nutrition and toxicology and on in vitro techniques, particularly those fostering the 3 Rs. The principal aim of the journal is to publish high impact, scholarly work and to serve as a multidisciplinary forum for research in toxicology. Papers submitted will be judged on the basis of scientific originality and contribution to the field, quality and subject matter. Studies should address at least one of the following: -Adverse physiological/biochemical, or pathological changes induced by specific defined substances -New techniques for assessing potential toxicity, including molecular biology -Mechanisms underlying toxic phenomena -Toxicological examinations of specific chemicals or consumer products, both those showing adverse effects and those demonstrating safety, that meet current standards of scientific acceptability. Authors must clearly and briefly identify what novel toxic effect (s) or toxic mechanism (s) of the chemical are being reported and what their significance is in the abstract. Furthermore, sufficient doses should be included in order to provide information on NOAEL/LOAEL values.