侵袭性甲状腺癌亚型的特征和预后标志物:回顾性研究

IF 1.5 Q4 ONCOLOGY
Cancer reports Pub Date : 2025-03-14 DOI:10.1002/cnr2.70131
Suhaib Radi, Mazin Al-Maghrabi, Saleh Binmahfooz, Miguel Franco, Richard Payne, Michael Tamilia
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引用次数: 0

摘要

目的甲状腺癌的发病率明显上升。侵袭性亚型甲状腺乳头状癌(AG-PTC)和高级别滤泡细胞源性恶性肿瘤(HGFM)是介于分化良好和未分化癌症之间的恶性肿瘤,其治疗需要明确。我们的研究目的是描述AG-PTC和HGFM的临床病理特征,并评估其预后价值。方法对agg - ptc或HGFM患者进行单中心回顾性研究。HGFM由低分化甲状腺癌(PDTC)和分化的高级别甲状腺癌患者组成。比较两组患者的临床表现、病理特征、分子标志物、特异性治疗及临床转归。结果在3244例甲状腺癌病例中,136例符合AG-PTC和HGFM标准。确诊时的平均年龄为49岁,以女性为主。中位随访时间为3年。AG-PTC组的持续或复发率为40.3%,HGFM组为29.3%,AG-PTC组死亡率为4.5%,HGFM组死亡率为1.8%。血管、淋巴血管侵犯和甲状腺外扩张的存在与持续或复发疾病的较高发生率相关(风险比分别为2.5、3.8和4.2;p < 0.05)。将Ki-67指数分为5组时,Ki-67≥20%组复发率较高。结论血管/淋巴血管侵犯、甲状腺外扩张和增殖指数Ki-67可能是预测预后不良的预后指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Characteristics and Prognostic Markers of Aggressive Subtypes of Thyroid Cancer: A Retrospective Study

Characteristics and Prognostic Markers of Aggressive Subtypes of Thyroid Cancer: A Retrospective Study

Objective

The prevalence of thyroid cancer has increased significantly. Aggressive subtypes of papillary thyroid cancer (AG-PTC) and high-grade follicular cell-derived malignancies (HGFM) are malignancies that lie between well-differentiated and undifferentiated cancers, and their management needs to be clarified. The aim of our study is to describe the clinicopathological characteristics of AG-PTC and HGFM and to assess their prognostic value.

Methods

This was a retrospective chart review study at single center of patients with AG-PTC or HGFM. HGFM comprised of patients with poorly differentiated thyroid cancer (PDTC) and differentiated high-grade thyroid carcinoma. The clinical presentation, pathological characteristics, molecular markers, specific treatments, and clinical outcomes were compared between the groups.

Results

Of the 3244 thyroid cancer charts reviewed, 136 met the criteria for AG-PTC and HGFM. The mean age at diagnosis was 49 years, with a predominance of women. The median follow-up duration was 3 years. The rate of persistent or recurrent disease was 40.3% in the AG-PTC group and 29.3% in the HGFM group, 4.5% died in the AG-PTC group, and 1.8% died in the HGFM group. The presence of vascular, lymphovascular invasion and extrathyroidal extension were associated with a higher incidence of persistent or recurrent disease (Hazard ratio: 2.5, 3.8, and 4.2, respectively; p < 0.05). When the Ki-67 index was divided into five groups, the recurrence rate was higher in the ≥ 20% Ki-67 group.

Conclusions

Possible prognostic markers for predicting worse prognosis include vascular/lymphovascular invasion, extrathyroidal extension, and the proliferative index Ki-67.

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来源期刊
Cancer reports
Cancer reports Medicine-Oncology
CiteScore
2.70
自引率
5.90%
发文量
160
审稿时长
17 weeks
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