雷公藤次生代谢物。相关内生菌:产生微生物、结构和生物活性

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC
Cuili Chen , Shan Lu , Yanmin Zou , Di Mao , Hideaki Kakeya
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引用次数: 0

摘要

内生菌已被认为是发现具有不同结构和生物活性的新型生物活性天然产物的重要来源。本文对雷公藤的内生菌进行了综述。本文综述了近30年来(1995-2024)从威福地相关内生菌中发现的生产微生物、化学多样性和代谢物的生物活性。本文系统综述了12种内生植物的101种代谢物及其生物活性。将101种代谢物与从威福地中分离出来的代谢物进行综合比较,发现威福地相关内生菌产生的代谢物结构不同,具有不同的生物活性。据我们所知,这是第一次全面概述与T. wilfordii相关的内生菌及其次生代谢产物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Secondary Metabolites from Tripterygium wilfordii Hook. f.‐Associated Endophytes: Producing Microbes, Structures, and Bioactivities

Secondary Metabolites from Tripterygium wilfordii Hook. f.‐Associated Endophytes: Producing Microbes, Structures, and Bioactivities
Endophytes have been recognized as important sources for discovering novel bioactive natural products with diverse structures and biological activities. This review focuses on the endophytes of Tripterygium wilfordii Hook. f. (T. wilfordii), a famous traditional medicinal plant, and summarizes the producing microbes, chemical diversities, and bioactivities of the metabolites discovered from the T. wilfordii ‐associated endophytes over the past thirty years (1995–2024). One hundred and one metabolites together with their bioactivities from twelve endophytes are systematically reviewed. A comprehensive comparison of the 101 metabolites with those isolated from T. wilfordii reveals that the T. wilfordii‐associated endophytes produce structurally distinct metabolites with diverse biological activities. To the best of our knowledge, this is the first holistic overview of the T. wilfordii‐associated endophytes and their secondary metabolites.
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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