茚二酚、茚二酚和茚二苯并呋喃通过中断异-纳扎罗夫反应

IF 2.8 4区 化学 Q1 CHEMISTRY, ORGANIC
Sineenart Attanonchai , Kasam Poonswat , Prof. Dr. Somsak Ruchirawat , Dr. Poonsakdi Ploypradith
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引用次数: 0

摘要

二级苯基或苯并羟基被2-茚、2/3-吲哚或2/3-苯并呋喃进行级联碳阳离子环化(CCC),然后被H-/烯丙基硅烷或富电子芳烃分子间亲核加成,也可归类为中断的异纳扎罗夫反应,提供了相应的茚-融合茚/吲哚/苯并呋喃支架。最初的CCC在两个新形成的相邻立体中心形成了反式关系,而后者在新的环结处提供了选择性的顺式立体控制。从非手性醇开始,该反应序列提供了含氧/氮的含烷融合环四环体系,产率中等至较高,在三个连续的手性中心上具有优异的立体选择性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Indenoindenes, Indenoindoles, and Indenobenzofurans via the Interrupted iso‐Nazarov Reaction

Indenoindenes, Indenoindoles, and Indenobenzofurans via the Interrupted iso‐Nazarov Reaction
The cascade carbocation cyclization (CCC) of the secondary benzylic, or the benzhydryl, carbocation by the 2‐indene, 2/3‐indole, or 2/3‐benzofuran followed by the intermolecular nucleophilic addition by H‐/allyl‐silane or electron‐rich arenes, also classifiable as the interrupted iso‐Nazarov reaction, provided the corresponding indane‐fused indane/indole/benzofuran scaffolds. The initial CCC forged the trans relationship at the two newly formed adjacent stereogenic centers while the latter provided the selective cis stereocontrol at the new ring junction. Starting from achiral alcohols, the reaction sequence furnished the oxygen/nitrogen‐containing indane fused‐ring tetracyclic systems in moderate to good yields with excellent stereoselectivity on all three contiguous chiral centers.
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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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