Caroline Fernandes da Costa, Caroline de Almeida Reis, Jennifer Maia Alves da Silva, Julliany Taverny Sousa, Patrícia Teixeira de Oliveira, Joabe dos Santos Pereira, Lélia Maria Guedes Queiroz
{"title":"Amyloidosis associated with multiple myeloma: case report","authors":"Caroline Fernandes da Costa, Caroline de Almeida Reis, Jennifer Maia Alves da Silva, Julliany Taverny Sousa, Patrícia Teixeira de Oliveira, Joabe dos Santos Pereira, Lélia Maria Guedes Queiroz","doi":"10.1016/j.oooo.2025.01.063","DOIUrl":null,"url":null,"abstract":"<div><div>Amyloidosis is a debilitating disease with systemic or local manifestation characterized by progressive extracellular deposition of insoluble proteins that can affect multiple organs. A 72-year-old male patient, with a history of hyperthyroidism, dysphagia, and weight loss, was referred by the physician due to edema and erythema on the tongue. Upon extraoral examination, petechiae near the eyes and hemorrhagic discharge in the right eye were observed. Intraoral examination revealed macroglossia and normochromic nodular lesions on the tongue, as well as petechiae on the palate and buccal mucosa. With clinical suspicion of amyloidosis, an incisional biopsy was performed. Histopathological examination revealed extracellular deposits of homogeneous eosinophilic amorphous material, suggestive of amyloidosis. The diagnosis was confirmed through histochemical examination with Congo red stain. The patient was referred to the medical service for investigation of multifocal organ involvement, was diagnosed with multiple myeloma, and is currently undergoing chemotherapy treatment.</div></div>","PeriodicalId":49010,"journal":{"name":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","volume":"139 5","pages":"Page e12"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Surgery Oral Medicine Oral Pathology Oral Radiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212440325000665","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
Amyloidosis associated with multiple myeloma: case report
Amyloidosis is a debilitating disease with systemic or local manifestation characterized by progressive extracellular deposition of insoluble proteins that can affect multiple organs. A 72-year-old male patient, with a history of hyperthyroidism, dysphagia, and weight loss, was referred by the physician due to edema and erythema on the tongue. Upon extraoral examination, petechiae near the eyes and hemorrhagic discharge in the right eye were observed. Intraoral examination revealed macroglossia and normochromic nodular lesions on the tongue, as well as petechiae on the palate and buccal mucosa. With clinical suspicion of amyloidosis, an incisional biopsy was performed. Histopathological examination revealed extracellular deposits of homogeneous eosinophilic amorphous material, suggestive of amyloidosis. The diagnosis was confirmed through histochemical examination with Congo red stain. The patient was referred to the medical service for investigation of multifocal organ involvement, was diagnosed with multiple myeloma, and is currently undergoing chemotherapy treatment.
期刊介绍:
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.