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IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-03-14 DOI:10.1016/j.oooo.2025.01.051

Liova Amaru Chabot-Diaz, Fabrício Bitu Sousa, Ana Paula Negreiros Nunes Alves, Karuza Maria Alves Pereira, Farah Essguí Orellana Martinez, Alana Lima dos Santos, Mário Rógerio Lima Mota

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引用次数: 0

摘要

淋巴上皮癌（LEC）很少发生在口腔，而与爱泼斯坦-巴氏病毒（EBV）相关的病变则常见于鼻咽部病变。一名 85 岁女性的舌尖结节被送去活检。临床表现为椭圆形、无梗、坚硬、正常肤色。组织病理分析表明，这是一种恶性肿瘤，由孤立或排列成岛状和条索状的表皮细胞组成，呈现合胞状。细胞呈多形性，核呈水泡状，内含嗜酸性大核。基质呈明显的淋巴样，有少量嗜酸性粒细胞。淋巴细胞穿透肿瘤增殖处，因此很难看到表皮细胞的岛状和条索状。肿瘤细胞经抗CKPool、抗EMA和抗EBV免疫染色，提示诊断为LEC。患者被转到头颈部科接受肿瘤治疗。组织病理学和免疫组化相结合是诊断 LEC 的关键。口腔病变也可能与 EBV 有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Lymphoepithelial carcinoma at the lingual apex: a case report

Lymphoepithelial carcinoma (LEC) rarely occurs in the oral cavity, an association with Epstein-Barr virus (EBV) is commonly observed in nasopharyngeal lesions. A biopsy of a lingual apex nodule was sent from an 85-year-old female. Clinically, the lesion was described as oval, sessile, firm, and normochromic. Histopathological analysis showed a malignant neoplasm composed of epidermoid cells isolated or arranged in islands and cords, exhibiting a syncytial appearance. The cells were pleomorphic, with vesiculated nuclei containing acidophilic macronuclei. The stroma was markedly lymphoid with few eosinophils. It penetrated the tumor proliferation, making it difficult to visualize the islands and cords of epidermoid cells. Tumor cells were immunostained for anti-CKPool, anti-EMA, and anti-EBV, suggesting a diagnosis of LEC. The patient was referred to the Head and Neck Service for oncologic treatment. A combination of histopathology and immunohistochemistry is essential for the diagnosis of LEC. Oral lesions may also be associated with EBV.

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.