{"title":"Preparation and assessment of polylactic acid-curcumin nanofibrous wound dressing containing silver nanoparticles for burn wound treatment","authors":"Mehri Moayedi , Tahmineh Ahmadi , Vahid Nekouie , Majid Taghian Dehaghani , Shahrokh Shojaei , Soheila Zamalui Benisi , Hamid Reza Bakhsheshi-Rad","doi":"10.1016/j.burns.2025.107442","DOIUrl":null,"url":null,"abstract":"<div><div>This study aims to produce and evaluate nanofibrous wound dressings through the electrospinning method, utilizing polylactic acid (PLA), curcumin (Cur), and silver nanoparticles (AgNPs). For this purpose, five types of wound dressings with PLA, PLA+Cur, PLA+Cur+ 1 %AgNPs, PLA+Cur+ 2 %AgNPs and PLA+Cur+ 3 %AgNPs were produced using the electrospinning method. Analysis of the Fourier transform infrared spectroscopy and scanning electron microscopic observations indicated successful fabrication, with nanometer diameters achieved in all electrospun samples. Examination of water absorption of wound dressings revealed that over 40 h the electrospun samples had variable water absorption between 0 % and 0.25 %. The results of the curcumin release test over one week showed that the nanofibers with PLA+Cur+ 2 %AgNPs exhibited the lowest release rate, while those with PLA+Cur+ 3 %AgNPs showed the highest release. Assessment of mechanical properties revealed that the tensile strength of the nanofibers increased by adding curcumin to polylactic acid, while the addition of a high content of AgNPs led to a decrease in tensile strength. Also, the PLA+Cur dressing demonstrated 84.06 % and the PLA+Cur+ 3 %AgNPs dressing exhibited 99.12 % antibacterial properties. The cell culture test demonstrated that the incorporation of curcumin and AgNPs increasedboth the growth and proliferation, as well as the adhesion on the nanofibrous wound dressing. Thus, the PLA+Cur+ 1 %AgNPs nanofibrous scaffold, as a multipurpose dressing, presented considerable promise for wound healing and burn treatment.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107442"},"PeriodicalIF":3.2000,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Burns","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0305417925000713","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CRITICAL CARE MEDICINE","Score":null,"Total":0}
Preparation and assessment of polylactic acid-curcumin nanofibrous wound dressing containing silver nanoparticles for burn wound treatment
This study aims to produce and evaluate nanofibrous wound dressings through the electrospinning method, utilizing polylactic acid (PLA), curcumin (Cur), and silver nanoparticles (AgNPs). For this purpose, five types of wound dressings with PLA, PLA+Cur, PLA+Cur+ 1 %AgNPs, PLA+Cur+ 2 %AgNPs and PLA+Cur+ 3 %AgNPs were produced using the electrospinning method. Analysis of the Fourier transform infrared spectroscopy and scanning electron microscopic observations indicated successful fabrication, with nanometer diameters achieved in all electrospun samples. Examination of water absorption of wound dressings revealed that over 40 h the electrospun samples had variable water absorption between 0 % and 0.25 %. The results of the curcumin release test over one week showed that the nanofibers with PLA+Cur+ 2 %AgNPs exhibited the lowest release rate, while those with PLA+Cur+ 3 %AgNPs showed the highest release. Assessment of mechanical properties revealed that the tensile strength of the nanofibers increased by adding curcumin to polylactic acid, while the addition of a high content of AgNPs led to a decrease in tensile strength. Also, the PLA+Cur dressing demonstrated 84.06 % and the PLA+Cur+ 3 %AgNPs dressing exhibited 99.12 % antibacterial properties. The cell culture test demonstrated that the incorporation of curcumin and AgNPs increasedboth the growth and proliferation, as well as the adhesion on the nanofibrous wound dressing. Thus, the PLA+Cur+ 1 %AgNPs nanofibrous scaffold, as a multipurpose dressing, presented considerable promise for wound healing and burn treatment.
期刊介绍:
Burns aims to foster the exchange of information among all engaged in preventing and treating the effects of burns. The journal focuses on clinical, scientific and social aspects of these injuries and covers the prevention of the injury, the epidemiology of such injuries and all aspects of treatment including development of new techniques and technologies and verification of existing ones. Regular features include clinical and scientific papers, state of the art reviews and descriptions of burn-care in practice.
Topics covered by Burns include: the effects of smoke on man and animals, their tissues and cells; the responses to and treatment of patients and animals with chemical injuries to the skin; the biological and clinical effects of cold injuries; surgical techniques which are, or may be relevant to the treatment of burned patients during the acute or reconstructive phase following injury; well controlled laboratory studies of the effectiveness of anti-microbial agents on infection and new materials on scarring and healing; inflammatory responses to injury, effectiveness of related agents and other compounds used to modify the physiological and cellular responses to the injury; experimental studies of burns and the outcome of burn wound healing; regenerative medicine concerning the skin.