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IF 3.2 3区医学 Q2 CRITICAL CARE MEDICINE

Burns Pub Date : 2025-02-27 DOI:10.1016/j.burns.2025.107442

Mehri Moayedi , Tahmineh Ahmadi , Vahid Nekouie , Majid Taghian Dehaghani , Shahrokh Shojaei , Soheila Zamalui Benisi , Hamid Reza Bakhsheshi-Rad

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引用次数: 0

摘要

本研究旨在利用聚乳酸（PLA）、姜黄素（Cur）和纳米银颗粒（AgNPs），通过电纺丝方法生产和评估纳米纤维伤口敷料。为此，利用电纺丝法生产了五种类型的伤口敷料，分别含有聚乳酸、聚乳酸+姜黄素、聚乳酸+姜黄素+ 1 %银纳米粒子、聚乳酸+姜黄素+ 2 %银纳米粒子和聚乳酸+姜黄素+ 3 %银纳米粒子。傅立叶变换红外光谱分析和扫描电子显微镜观察结果表明，所有电纺丝样品的直径都达到了纳米级。对伤口敷料吸水性的检测表明，在 40 小时内，电纺样品的吸水性在 0 % 到 0.25 % 之间。一周的姜黄素释放测试结果表明，含有 PLA+Cur+ 2 %AgNPs 的纳米纤维的释放率最低，而含有 PLA+Cur+ 3 %AgNPs 的纳米纤维的释放率最高。机械性能评估显示，在聚乳酸中添加姜黄素后，纳米纤维的拉伸强度增加，而添加高含量的 AgNPs 则导致拉伸强度下降。此外，聚乳酸+姜黄素敷料的抗菌性能为 84.06%，聚乳酸+姜黄素+3%AgNPs 敷料的抗菌性能为 99.12%。细胞培养测试表明，姜黄素和 AgNPs 的加入提高了纳米纤维伤口敷料的生长、增殖和粘附性。因此，聚乳酸+姜黄素+1%AgNPs纳米纤维支架作为一种多用途敷料，在伤口愈合和烧伤治疗方面前景广阔。

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Preparation and assessment of polylactic acid-curcumin nanofibrous wound dressing containing silver nanoparticles for burn wound treatment

This study aims to produce and evaluate nanofibrous wound dressings through the electrospinning method, utilizing polylactic acid (PLA), curcumin (Cur), and silver nanoparticles (AgNPs). For this purpose, five types of wound dressings with PLA, PLA+Cur, PLA+Cur+ 1 %AgNPs, PLA+Cur+ 2 %AgNPs and PLA+Cur+ 3 %AgNPs were produced using the electrospinning method. Analysis of the Fourier transform infrared spectroscopy and scanning electron microscopic observations indicated successful fabrication, with nanometer diameters achieved in all electrospun samples. Examination of water absorption of wound dressings revealed that over 40 h the electrospun samples had variable water absorption between 0 % and 0.25 %. The results of the curcumin release test over one week showed that the nanofibers with PLA+Cur+ 2 %AgNPs exhibited the lowest release rate, while those with PLA+Cur+ 3 %AgNPs showed the highest release. Assessment of mechanical properties revealed that the tensile strength of the nanofibers increased by adding curcumin to polylactic acid, while the addition of a high content of AgNPs led to a decrease in tensile strength. Also, the PLA+Cur dressing demonstrated 84.06 % and the PLA+Cur+ 3 %AgNPs dressing exhibited 99.12 % antibacterial properties. The cell culture test demonstrated that the incorporation of curcumin and AgNPs increasedboth the growth and proliferation, as well as the adhesion on the nanofibrous wound dressing. Thus, the PLA+Cur+ 1 %AgNPs nanofibrous scaffold, as a multipurpose dressing, presented considerable promise for wound healing and burn treatment.

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来源期刊

Burns 医学-皮肤病学

CiteScore

4.50

自引率

18.50%

发文量

304

审稿时长

72 days

期刊介绍： Burns aims to foster the exchange of information among all engaged in preventing and treating the effects of burns. The journal focuses on clinical, scientific and social aspects of these injuries and covers the prevention of the injury, the epidemiology of such injuries and all aspects of treatment including development of new techniques and technologies and verification of existing ones. Regular features include clinical and scientific papers, state of the art reviews and descriptions of burn-care in practice. Topics covered by Burns include: the effects of smoke on man and animals, their tissues and cells; the responses to and treatment of patients and animals with chemical injuries to the skin; the biological and clinical effects of cold injuries; surgical techniques which are, or may be relevant to the treatment of burned patients during the acute or reconstructive phase following injury; well controlled laboratory studies of the effectiveness of anti-microbial agents on infection and new materials on scarring and healing; inflammatory responses to injury, effectiveness of related agents and other compounds used to modify the physiological and cellular responses to the injury; experimental studies of burns and the outcome of burn wound healing; regenerative medicine concerning the skin.