吲哚菁绿介导的抗菌光动力疗法:一种非侵入性治疗慢性牙周炎合并2型糖尿病的方法:一项随机对照临床试验

Q1 Medicine
Priyanka Agarwal, Pratibha Shashikumar, Rakshitha S
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引用次数: 0

摘要

牙周炎是牙周组织的一种破坏性慢性炎症性疾病,是导致牙齿脱落的主要原因。不受控制的糖尿病影响牙周状态,慢性牙周炎影响血糖状态。非手术牙周治疗往往不足以完全消除病原体。因此,抗菌素光动力疗法(aPDT)正被用于医学上有缺陷的患者,因为它不会引起其他辅助治疗所见的不良反应。本研究旨在评价吲哚菁绿抗菌光动力疗法辅助刮治和根治治疗2型糖尿病合并慢性广泛性牙周炎的疗效。目的是观察临床参数和微生物参数的改善及其对血糖水平的影响。材料与方法将40例慢性牙周炎合并2型糖尿病患者随机分为试验组和对照组,每组18人。试验组接受。刮治和根刨(SRP) + aPDT),而对照组仅接受SRP。SRP + aPDT组,用吲哚菁绿冲洗后,用二极管激光照射袋部。评估临床参数,如斑块指数(PI)、牙龈指数(GI)、探测深度(PD)、临床附着水平(CAL)和糖化血红蛋白(HbA1c),以及牙龈卟啉单胞菌(Pg)和放线菌聚集杆菌(Aa)的微生物学分析。治疗后3个月及资料进行统计学分析。结果apdt辅助SRP可改善临床和微生物学参数。统计学上有显著差异(p <;组间比较PD、CAL和Pg和Aa的菌落形成单位(CFU/ml)的差异为0.001)。从基线到3个月,两组的HbA1c水平都有所改善,但在3个月时,两组之间没有显著差异。结论吲哚菁绿介导的aPDT辅助治疗2型糖尿病患者慢性牙周炎,可显著降低微生物计数,并获得额外的临床益处。临床意义apdt作为SRP的辅助治疗可作为2型糖尿病等医学上有缺陷的慢性牙周炎患者的非侵入性治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Indocyanine green mediated antimicrobial photodynamic therapy: A non-invasive treatment approach for chronic periodontitis with type 2 diabetes mellitus: A randomized controlled clinical trial

Indocyanine green mediated antimicrobial photodynamic therapy: A non-invasive treatment approach for chronic periodontitis with type 2 diabetes mellitus: A randomized controlled clinical trial

Background

Periodontitis is a destructive chronic inflammatory disorder of the periodontium and is a major cause of loss of teeth. Uncontrolled diabetes affects periodontal status and chronic periodontitis affects the glycemic status. Nonsurgical periodontal therapy is often not sufficient in completely eliminating the pathogens. Hence antimicrobial photodynamic therapy (aPDT), is being used in medically compromised patients as it does not cause adverse effects that are seen with other adjunctive treatments. This study aimed to evaluate the efficacy of antimicrobial photodynamic therapy using Indocyanine green as an adjunct to scaling and root planing in the treatment of periodontitis in controlled Type 2 Diabetes Mellitus (DM) patients with chronic generalized periodontitis. The objective to see improvements in clinical parameters and microbiological parameters along with its effect on glycemic levels.

Materials and methods

In this randomized controlled clinical trial a total of 40 chronic periodontitis patients with Type 2 DM were randomly assigned into test and control groups of 18 participants each. The test group received.
Scaling and root planing (SRP) + aPDT) while the control group received only SRP. In SRP + aPDT group, pockets were irradiated with a diode laser after irrigation with Indocyanine green. Assessment of clinical parameters like plaque index (PI), gingival index (GI), probing depth, (PD), clinical attachment level (CAL), and glycated haemoglobin (HbA1c), as well as microbiological analysis for Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetem comitans (Aa) was done at baseline & 3 months post-therapy and data were statistically analysed.

Results

aPDT as an adjunct to SRP improved clinical and microbiological parameters. A statistically significant difference (p < 0.001) was noted on intergroup comparison with respect to PD, CAL, and colony forming units (CFU/ml) of Pg and Aa. There was an improvement in HbA1c levels from baseline to 3 months in both the groups however, there was no significant difference between the groups at 3 months.

Conclusion

The use of Indocyanine green mediated aPDT as adjuvant therapy in treatment of chronic periodontitis in Type 2 diabetes mellitus patients resulted in significant reduction in microbial counts as well as rendered additional clinical benefits.

Clinical significance

aPDT as adjunctive therapy to SRP can be a non-invasive treatment of choice for chronic periodontitis in medically compromised patients like Type 2 Diabetes mellitus patients.
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来源期刊
CiteScore
4.90
自引率
0.00%
发文量
133
审稿时长
167 days
期刊介绍: Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.
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