合成核肽和核苷酸的动力学捕获自组装

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-03-14 DOI:10.1039/d4cc06524g

Shubhasree Das , Rongali G. Sravani , Shibaji Basak

引用次数: 0

摘要

大自然经常使用热力学上不利的动态自组装来执行细胞功能。一个核肽和ATP形成自组装水凝胶。肽和AMP不能形成水凝胶。值得注意的是，当ATP被ATP酶原位水解成AMP时，肽-AMP组合物仍然是自组装的水凝胶，表现出不同寻常的动力学捕获自组装

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Kinetically trapped self-assembly in synthetic nucleopeptides and nucleotides†

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Kinetically trapped self-assembly in synthetic nucleopeptides and nucleotides†

Nature uses thermodynamically unfavourable dynamic self-assembly to execute cellular functions frequently. A nucleopeptide and ATP formed a self-assembled hydrogel. The peptide and AMP were unable to form a hydrogel. Notably, when ATP was hydrolyzed to AMP in situ by an ATPase enzyme, the peptide–AMP composition remained a self-assembled hydrogel, showing unusual kinetically trapped self-assembly.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.