台湾某地区医院新冠肺炎大流行前后住院患者鼻腔耐甲氧西林金黄色葡萄球菌携带情况。

IF 3.7 2区医学 Q2 IMMUNOLOGY

Journal of Microbiology Immunology and Infection Pub Date : 2025-03-04 DOI:10.1016/j.jmii.2025.02.011

Fang-Ching Liu , Cheng-Lun Li , Yi-Ching Huang , Yhu-Chering Huang

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引用次数: 0

摘要

背景：在新冠肺炎大流行期间，台湾医院实施了严格的口罩佩戴和洗手。为探讨2019冠状病毒病（COVID-19）感染前后住院患者鼻腔耐甲氧西林金黄色葡萄球菌（MRSA）携带率的变化情况，我们进行了这项研究。方法：选取2012年和2023年在台湾中部某地区医院住院1周的患者为研究对象。每位受试者在获得书面知情同意后，取鼻拭子进行MRSA检测。分析MRSA携带的危险因素及MRSA的微生物学特征。结果：总体而言，2012年鼻腔MRSA携带率为6.2%(31/502)，2023年为8.0%（40/499）。除儿科患者外，与MRSA携带显著相关的危险因素包括2012年的变应性鼻炎、胸管插入、慢性阻塞性肺疾病，以及2023年近期MRSA培养阳性、上一年度使用抗生素。2012年，最常见的两种菌株为ST 59/脉冲型C/葡萄球菌染色体卡式（SCCmec） IV/潘顿-瓦朗丁白细胞素（PVL）阴性（35.5%）和ST 59/脉冲型D/SCCmec VT/PVL阳性（19.4%），而最常见的两种菌株在2023年转变为ST 45（及其单位点变异）/脉冲型AK/SCCmec IV/PVL阴性（30.0%）和ST 8/脉冲型AI/SCCmec IV/PVL阳性（22.5%）。结论：台湾省住院患者鼻腔MRSA携带率未受2019冠状病毒病疫情影响。定植的MRSA分离株的分子特征从两个本地特有的群落菌株ST 59转变为两个新出现的进口菌株ST 45和ST 8。

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Nasal methicillin-resistant Staphylococcus aureus carriage among hospitalized patients before and after COVID-19 pandemic in a regional hospital in taiwan

Background

Strict mask wearing and handwashing were implemented in hospital settings during COVID-19 pandemic in Taiwan. To explore if nasal methicillin-resistant Staphylococcus aureus (MRSA) carriage rate among inpatients in the hospital changed before and after COVID-19, we conducted this study.

Methods

Patients who were admitted to a regional hospital in central Taiwan during one week in 2012 and 2023, respectively, were enrolled. A nasal swab from each subject was obtained for MRSA detection after a written informed consent was obtained. Risk factors of MRSA carriage, and microbiologic characteristics of MRSA were analyzed.

Results

Overall, nasal MRSA carriage rate was 6.2 % (31/502) in 2012 and 8.0 % (40/499) in 2023. In addition to pediatric patients, risk factors significantly associated with MRSA carriage included allergic rhinitis, chest tube insertion, chronic obstructive pulmonary disease in 2012 and recent positive MRSA culture, antimicrobial usage within previous year in 2023. In 2012, the two most common strains were ST 59/pulsotype C/staphylococcal chromosomal cassette (SCCmec) IV/Panton-Valentine leucocidin (PVL)-negative (35.5 %) and ST 59/pulsotype D/SCCmec V_T/PVL positive (19.4 %) while the two most common strains shifted to ST 45 (and its single locus variant)/pulsotype AK/SCCmec IV/PVL-negative (30.0 %) and ST 8/pulsotype AI/SCCmec IV/PVL positive (22.5 %) in 2023.

Conclusions

Nasal MRSA carriage rate among inpatients in the hospital setting was not affected by the COVID-19 pandemic in Taiwan. Molecular characteristics of colonizing MRSA isolates shifted from two local endemic community strains of ST 59 to two emerging imported strains of ST 45 and ST 8.

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来源期刊

Journal of Microbiology Immunology and Infection IMMUNOLOGY-INFECTIOUS DISEASES

CiteScore

15.90

自引率

5.40%

发文量

159

审稿时长

67 days

期刊介绍： Journal of Microbiology Immunology and Infection is an open access journal, committed to disseminating information on the latest trends and advances in microbiology, immunology, infectious diseases and parasitology. Article types considered include perspectives, review articles, original articles, brief reports and correspondence. With the aim of promoting effective and accurate scientific information, an expert panel of referees constitutes the backbone of the peer-review process in evaluating the quality and content of manuscripts submitted for publication.