{"title":"1990 至 2021 年全球、地区和国家与烟草相关的神经系统疾病负担：趋势和未来预测。","authors":"Chenyang Zhang, Zhihan An, Jixuan Jiang, Jingyi Ge, Wanqiong Huang, Jialin Pei, Yiyao Liu, Jiayu Yao, Zirui Guo, Xuanxi Liu, Yanhui Cui","doi":"10.18332/tid/201966","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Tobacco use is as a major public health concern around the world, adversely impacting quality of life. Our study aims to analyze the trends in the burden of tobacco-related neurological disorders (ND) at global, regional, and national levels from 1990 to 2021, as well as potential future trends.</p><p><strong>Methods: </strong>We performed a secondary dataset analysis for the assessment of mortality and disability-adjusted life years (DALYs) using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, to explore the burden of tobacco-related ND. We also analyzed the associations between the burden of ND and factors such as age, gender, and the Sociodemographic Index (SDI).</p><p><strong>Results: </strong>In 2021, the age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR) for neurological disorders were 0.50 per 100000 persons (95% UI: -0.15-1.98) and 11.25 per 100000 persons (95% UI: 1.36-34.36), respectively. Alzheimer's disease and other dementias (ADOD) had a particularly significant impact on the burden of ND. However, the ASDR for Parkinson's disease was -8.38 per 100000 persons (95% UI: -10.72 - -6.20). The burden of disease was greater in men and older people, with substantial regional variation. While aging and population growth might contribute to the increase in DALYs for tobacco-related ND, epidemiological changes have the potential to reduce the burden. From 2022 to 2050, the BAPC model predicted a decline in the age-standardized rate (ASR) of DALYs and mortality for tobacco-related ND, globally.</p><p><strong>Conclusions: </strong>Tobacco use increased the burden of ND such as ADOD and multiple sclerosis (MS), while reducing the burden of Parkinson's disease (PD). The burden of disease was disproportionately higher among older individuals and males, with significant disparities across nations and regions. Over the past 32 years, the burden of these diseases has gradually decreased, and this trend is expected to continue from 2022 to 2050.</p>","PeriodicalId":23202,"journal":{"name":"Tobacco Induced Diseases","volume":"23 ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897908/pdf/","citationCount":"0","resultStr":"{\"title\":\"Global, regional, and national burden of tobacco-related neurological disorders from 1990 to 2021: Trends and future projections.\",\"authors\":\"Chenyang Zhang, Zhihan An, Jixuan Jiang, Jingyi Ge, Wanqiong Huang, Jialin Pei, Yiyao Liu, Jiayu Yao, Zirui Guo, Xuanxi Liu, Yanhui Cui\",\"doi\":\"10.18332/tid/201966\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Tobacco use is as a major public health concern around the world, adversely impacting quality of life. Our study aims to analyze the trends in the burden of tobacco-related neurological disorders (ND) at global, regional, and national levels from 1990 to 2021, as well as potential future trends.</p><p><strong>Methods: </strong>We performed a secondary dataset analysis for the assessment of mortality and disability-adjusted life years (DALYs) using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, to explore the burden of tobacco-related ND. We also analyzed the associations between the burden of ND and factors such as age, gender, and the Sociodemographic Index (SDI).</p><p><strong>Results: </strong>In 2021, the age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR) for neurological disorders were 0.50 per 100000 persons (95% UI: -0.15-1.98) and 11.25 per 100000 persons (95% UI: 1.36-34.36), respectively. Alzheimer's disease and other dementias (ADOD) had a particularly significant impact on the burden of ND. However, the ASDR for Parkinson's disease was -8.38 per 100000 persons (95% UI: -10.72 - -6.20). The burden of disease was greater in men and older people, with substantial regional variation. While aging and population growth might contribute to the increase in DALYs for tobacco-related ND, epidemiological changes have the potential to reduce the burden. From 2022 to 2050, the BAPC model predicted a decline in the age-standardized rate (ASR) of DALYs and mortality for tobacco-related ND, globally.</p><p><strong>Conclusions: </strong>Tobacco use increased the burden of ND such as ADOD and multiple sclerosis (MS), while reducing the burden of Parkinson's disease (PD). The burden of disease was disproportionately higher among older individuals and males, with significant disparities across nations and regions. Over the past 32 years, the burden of these diseases has gradually decreased, and this trend is expected to continue from 2022 to 2050.</p>\",\"PeriodicalId\":23202,\"journal\":{\"name\":\"Tobacco Induced Diseases\",\"volume\":\"23 \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-03-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897908/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tobacco Induced Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.18332/tid/201966\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tobacco Induced Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.18332/tid/201966","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Global, regional, and national burden of tobacco-related neurological disorders from 1990 to 2021: Trends and future projections.
Introduction: Tobacco use is as a major public health concern around the world, adversely impacting quality of life. Our study aims to analyze the trends in the burden of tobacco-related neurological disorders (ND) at global, regional, and national levels from 1990 to 2021, as well as potential future trends.
Methods: We performed a secondary dataset analysis for the assessment of mortality and disability-adjusted life years (DALYs) using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, to explore the burden of tobacco-related ND. We also analyzed the associations between the burden of ND and factors such as age, gender, and the Sociodemographic Index (SDI).
Results: In 2021, the age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR) for neurological disorders were 0.50 per 100000 persons (95% UI: -0.15-1.98) and 11.25 per 100000 persons (95% UI: 1.36-34.36), respectively. Alzheimer's disease and other dementias (ADOD) had a particularly significant impact on the burden of ND. However, the ASDR for Parkinson's disease was -8.38 per 100000 persons (95% UI: -10.72 - -6.20). The burden of disease was greater in men and older people, with substantial regional variation. While aging and population growth might contribute to the increase in DALYs for tobacco-related ND, epidemiological changes have the potential to reduce the burden. From 2022 to 2050, the BAPC model predicted a decline in the age-standardized rate (ASR) of DALYs and mortality for tobacco-related ND, globally.
Conclusions: Tobacco use increased the burden of ND such as ADOD and multiple sclerosis (MS), while reducing the burden of Parkinson's disease (PD). The burden of disease was disproportionately higher among older individuals and males, with significant disparities across nations and regions. Over the past 32 years, the burden of these diseases has gradually decreased, and this trend is expected to continue from 2022 to 2050.
期刊介绍：
Tobacco Induced Diseases encompasses all aspects of research related to the prevention and control of tobacco use at a global level. Preventing diseases attributable to tobacco is only one aspect of the journal, whose overall scope is to provide a forum for the publication of research articles that can contribute to reducing the burden of tobacco induced diseases globally. To address this epidemic we believe that there must be an avenue for the publication of research/policy activities on tobacco control initiatives that may be very important at a regional and national level. This approach provides a very important "hands on" service to the tobacco control community at a global scale - as common problems have common solutions. Hence, we see ourselves as "connectors" within this global community.
The journal hence encourages the submission of articles from all medical, biological and psychosocial disciplines, ranging from medical and dental clinicians, through health professionals to basic biomedical and clinical scientists.
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