在癌症研究中绘制维生素D的图景:一项系统的全球调查。

IF 1.6 Q4 ENDOCRINOLOGY & METABOLISM
Journal of Diabetes and Metabolic Disorders Pub Date : 2025-03-10 eCollection Date: 2025-06-01 DOI:10.1007/s40200-025-01594-9
Ali Faryabi, Mohammad Amin Salari, Alaleh Dalvand, Hassan Akbarniakhaky, Ghazal Mohammadi, Hossein Aazami, Farideh Razi, Hojat Dehghanbanadaki
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引用次数: 0

摘要

目的:这项综合性研究考察了维生素D与癌症之间的多方面关系,综合了关键的科学进展和全球研究趋势,以指导未来的研究和解决该领域的关键空白。方法:检索Scopus数据库截至2024年11月的有关维生素D与癌症的文献。使用Excel、VOSviewer和Scimago Graphica对英语原创和评论文章进行分析,重点关注出版趋势、引用影响和研究主题。结果:共收录文献11442篇,其中原创80.01%,综述19.98%;51.24%开放获取)。美国在出版物(38.3%)和引用(56.2%)方面领先,其次是中国(7.7%)和英国(7.2%)的产出,以及英国(10.6%)和德国(6.4%)的引用。每份文件引用次数最高的国家是比利时(103.4次)、斯洛文尼亚(87.9次)和波多黎各(76.6次)。与维生素D相关的最常见癌症分别是乳腺癌、结肠直肠癌、前列腺癌、皮肤癌、肺癌、卵巢癌、胰腺癌、胃癌、肝细胞癌、甲状腺癌、白血病、多发性骨髓瘤、膀胱癌、淋巴瘤、骨肉瘤、宫颈癌、子宫内膜癌和胶质母细胞瘤。聚类分析揭示了与维生素D相关的关键模式:骨化三醇在乳腺癌、前列腺癌和结肠直肠癌中的化学预防作用,饮食维生素D在卵巢癌中的作用,维生素D调节癌症相关的高钙血症,维生素D缺乏与炎症-肥胖-癌症风险有关,VDR多态性影响肺癌和结肠直肠癌的结果,维生素D对皮肤恶性肿瘤的光保护作用,以及维生素D在溃疡性结肠炎相关癌症中的作用。被引用最多的文章强调了最佳维生素D水平和癌症预防。结论:本研究强调了维生素D及其与癌症的复杂联系的广泛研究,强调了未来的前景,重点是精准医学方法,包括靶向补充和基因组分析,以更好地解决癌症预防和治疗中的个体差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mapping the landscape of vitamin D in cancer studies: a systematic global investigation.

Purpose: This comprehensive study examines the multifaceted relationship between vitamin D and cancer, synthesizing key scientific advancements and global research trends to guide future investigations and address critical gaps in the field.

Methods: Publications on vitamin D and cancer were retrieved from Scopus up to November 2024. English-language original and review articles were analyzed using Excel, VOSviewer, and Scimago Graphica, focusing on publication trends, citation impacts, and research themes.

Results: A total of 11,442 publications (80.01% original articles, 19.98% reviews; 51.24% open access) were analyzed. The United States of America led in publications (38.3%) and citations (56.2%), followed by China (7.7%) and the United Kingdom (7.2%) in output, and the United Kingdom (10.6%) and Germany (6.4%) in citations. Countries with the highest citations per document were Belgium (103.4), Slovenia (87.9), and Puerto Rico (76.6). The most frequently studied cancers in relation to vitamin D were breast, colorectal, prostate, skin, lung, ovarian, pancreatic, gastric, hepatocellular, thyroid, leukemia, multiple myeloma, bladder, lymphoma, osteosarcoma, cervical, endometrial, and glioblastoma, respectively. Cluster analysis revealed key patterns related to vitamin D: Calcitriol's chemopreventive role in breast, prostate, and colorectal cancers, dietary vitamin D for its involvement in ovarian cancer, vitamin D for regulation of cancer-related hypercalcemia, vitamin D deficiency links to inflammation-obesity-cancer risk, VDR polymorphisms affecting outcomes in lung and colorectal cancers, and vitamin D's photoprotective effects on skin malignancies, and vitamin D in ulcerative colitis-related cancer. The most cited articles emphasized optimal vitamin D levels and cancer prevention.

Conclusion: This study highlights the extensive research on vitamin D and its complex links to cancer, emphasizing future prospects with a focus on precision medicine approaches, including targeted supplementation and genomic analyses, to better address individual variability in cancer prevention and treatment.

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来源期刊
Journal of Diabetes and Metabolic Disorders
Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine
CiteScore
4.80
自引率
3.60%
发文量
210
期刊介绍: Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.
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