microRNA-34：一个多功能miRNA家族。

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Archives of biochemistry and biophysics Pub Date : 2025-03-10 DOI:10.1016/j.abb.2025.110382

Chen Wang, Ximei Yuan, Yuejun Fu

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引用次数: 0

摘要

MicroRNAs是内源性非编码小rna，由约22个核苷酸组成，广泛存在于真核细胞中，通过与靶基因的互补配对，在转录后水平调控基因表达，导致mRNA降解或翻译抑制。miR-34是进化过程中高度保守的miRNA。最近的研究发现，miR-34家族成员参与调节衰老、纤毛发生和免疫等生物过程。为了更全面地了解miR-34，本文综述了miR-34的功能演变，为进一步研究miR-34的相关功能提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

microRNA-34 family: A multifunctional miRNA family

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microRNA-34 family: A multifunctional miRNA family

MicroRNAs are endogenous non-coding small RNAs composed of about 22 nucleotides, which are widely found in eukaryotic cells and regulate gene expression at the post-transcriptional level through complementary pairing with target genes, leading to mRNA degradation or translation inhibition. MiR-34 family is a highly conserved miRNA family during evolution. Recent studies have found that members of the miR-34 family are involved in regulating biological processes such as aging, ciliogenesis, and immunity. To have a more comprehensive understanding of miR-34 family, this paper reviewed the functional evolution of miR-34 family, and provided a reference for further research on the related functions of miR-34.

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来源期刊

Archives of biochemistry and biophysics 生物-生化与分子生物学

CiteScore

7.40

自引率

0.00%

发文量

245

审稿时长

26 days

期刊介绍： Archives of Biochemistry and Biophysics publishes quality original articles and reviews in the developing areas of biochemistry and biophysics. Research Areas Include: • Enzyme and protein structure, function, regulation. Folding, turnover, and post-translational processing • Biological oxidations, free radical reactions, redox signaling, oxygenases, P450 reactions • Signal transduction, receptors, membrane transport, intracellular signals. Cellular and integrated metabolism.