住院儿童感染相关死亡率：2016 - 2021年中国多中心研究

IF 4.7 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health Pub Date : 2025-03-06 DOI:10.1016/j.jiph.2025.102743

Jiao Tian , Qi Li , Shiqi Cai , Xinyu Wang , Junhong Ai , Guoshuang Feng , Yueping Zeng , Ran Wang , Zhengde Xie

{"title":"住院儿童感染相关死亡率：2016 - 2021年中国多中心研究","authors":"Jiao Tian , Qi Li , Shiqi Cai , Xinyu Wang , Junhong Ai , Guoshuang Feng , Yueping Zeng , Ran Wang , Zhengde Xie","doi":"10.1016/j.jiph.2025.102743","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Hospitalized children experience mortality as a result of infections. Since the COVID-19 outbreak in early 2020, China's strict prevention measures have curbed pathogen transmission, altering infection-related epidemiology. The Futang Research Center of Pediatric Development has collected the face sheet of discharge medical records (FSMRs) data from 27 tertiary children's hospitals since January 2016, which facilitate us to investigate this issue. Moreover, this study focuses on hospitalized children aged 18 years old or younger.</div></div><div><h3>Methods</h3><div>This study analyzed data from the FSMRs of children who died from infections at 27 tertiary children’s hospitals across China between January 2016 and December 2021. Of these hospitals, 21 are located in provincial capitals. The data included gender, age, region, residence, year of admission, infections-associated causes of death, pathogens, length of stay, and expense.</div></div><div><h3>Results</h3><div>A total of 1130 hospitalized children died from infections, accounting for 18.8 % of all deaths and 0.015 % of the total hospitalizations in the database during the period. Boys had a higher fatality than girls across different regions, age groups, years. Among all age groups, 0–28 days and 29 days–1 year group (≤365 days) had a higher number and proportion of deaths than other age groups. In terms of year of admission, the COVID-19 period (2020–2021) had a lower number of infections related death cases than pre-COVID-19 period. Further analysis of infection-related causes indicated that sepsis was the most common cause of death, followed by pneumonia, central nervous system infection, shock, enteritis, and myocarditis. The pathogens (bacterium, virus, fungus) were identified in 30.6 % of children.</div></div><div><h3>Conclusions</h3><div>Infections are the significant cause of death among hospitalized children in China.</div></div>","PeriodicalId":16087,"journal":{"name":"Journal of Infection and Public Health","volume":"18 6","pages":"Article 102743"},"PeriodicalIF":4.7000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Infection-related mortality in hospitalized children: A multi-center study in China from 2016 to 2021\",\"authors\":\"Jiao Tian , Qi Li , Shiqi Cai , Xinyu Wang , Junhong Ai , Guoshuang Feng , Yueping Zeng , Ran Wang , Zhengde Xie\",\"doi\":\"10.1016/j.jiph.2025.102743\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Hospitalized children experience mortality as a result of infections. Since the COVID-19 outbreak in early 2020, China's strict prevention measures have curbed pathogen transmission, altering infection-related epidemiology. The Futang Research Center of Pediatric Development has collected the face sheet of discharge medical records (FSMRs) data from 27 tertiary children's hospitals since January 2016, which facilitate us to investigate this issue. Moreover, this study focuses on hospitalized children aged 18 years old or younger.</div></div><div><h3>Methods</h3><div>This study analyzed data from the FSMRs of children who died from infections at 27 tertiary children’s hospitals across China between January 2016 and December 2021. Of these hospitals, 21 are located in provincial capitals. The data included gender, age, region, residence, year of admission, infections-associated causes of death, pathogens, length of stay, and expense.</div></div><div><h3>Results</h3><div>A total of 1130 hospitalized children died from infections, accounting for 18.8 % of all deaths and 0.015 % of the total hospitalizations in the database during the period. Boys had a higher fatality than girls across different regions, age groups, years. Among all age groups, 0–28 days and 29 days–1 year group (≤365 days) had a higher number and proportion of deaths than other age groups. In terms of year of admission, the COVID-19 period (2020–2021) had a lower number of infections related death cases than pre-COVID-19 period. Further analysis of infection-related causes indicated that sepsis was the most common cause of death, followed by pneumonia, central nervous system infection, shock, enteritis, and myocarditis. The pathogens (bacterium, virus, fungus) were identified in 30.6 % of children.</div></div><div><h3>Conclusions</h3><div>Infections are the significant cause of death among hospitalized children in China.</div></div>\",\"PeriodicalId\":16087,\"journal\":{\"name\":\"Journal of Infection and Public Health\",\"volume\":\"18 6\",\"pages\":\"Article 102743\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2025-03-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Infection and Public Health\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1876034125000929\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Infection and Public Health","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1876034125000929","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

摘要

住院儿童因感染而死亡。自2020年初新冠肺炎疫情爆发以来，中国严格的预防措施遏制了病原体的传播，改变了与感染相关的流行病学。福堂儿科发展研究中心收集了2016年1月以来27家三级儿童医院出院病历（FSMRs）数据面表，便于我们对这一问题进行调查。此外，本研究以18岁以下住院儿童为研究对象。方法本研究分析了2016年1月至2021年12月中国27家三级儿童医院感染死亡儿童的fsmr数据。在这些医院中，21家位于省会城市。数据包括性别、年龄、地区、居住地、入院年份、感染相关死亡原因、病原体、住院时间和费用。结果住院儿童感染死亡1130例，占死亡总数的18.8 %，占住院总人数的0.015 %。在不同地区、年龄组和年份，男孩的死亡率高于女孩。在所有年龄组中，0-28天组和29天- 1岁组（≤365天）的死亡人数和比例高于其他年龄组。从入院年份来看，新冠肺炎期间（2020-2021年）感染相关死亡病例数量低于新冠肺炎前期。对感染相关原因的进一步分析表明，败血症是最常见的死亡原因，其次是肺炎、中枢神经系统感染、休克、肠炎和心肌炎。病原菌（细菌、病毒、真菌）检出率为30.6% %。结论感染是中国住院儿童死亡的主要原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Infection-related mortality in hospitalized children: A multi-center study in China from 2016 to 2021

Background

Hospitalized children experience mortality as a result of infections. Since the COVID-19 outbreak in early 2020, China's strict prevention measures have curbed pathogen transmission, altering infection-related epidemiology. The Futang Research Center of Pediatric Development has collected the face sheet of discharge medical records (FSMRs) data from 27 tertiary children's hospitals since January 2016, which facilitate us to investigate this issue. Moreover, this study focuses on hospitalized children aged 18 years old or younger.

Methods

This study analyzed data from the FSMRs of children who died from infections at 27 tertiary children’s hospitals across China between January 2016 and December 2021. Of these hospitals, 21 are located in provincial capitals. The data included gender, age, region, residence, year of admission, infections-associated causes of death, pathogens, length of stay, and expense.

Results

A total of 1130 hospitalized children died from infections, accounting for 18.8 % of all deaths and 0.015 % of the total hospitalizations in the database during the period. Boys had a higher fatality than girls across different regions, age groups, years. Among all age groups, 0–28 days and 29 days–1 year group (≤365 days) had a higher number and proportion of deaths than other age groups. In terms of year of admission, the COVID-19 period (2020–2021) had a lower number of infections related death cases than pre-COVID-19 period. Further analysis of infection-related causes indicated that sepsis was the most common cause of death, followed by pneumonia, central nervous system infection, shock, enteritis, and myocarditis. The pathogens (bacterium, virus, fungus) were identified in 30.6 % of children.

Conclusions

Infections are the significant cause of death among hospitalized children in China.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of Infection and Public Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -INFECTIOUS DISEASES

CiteScore

13.10

自引率

1.50%

发文量

203

审稿时长

96 days

期刊介绍： The Journal of Infection and Public Health, first official journal of the Saudi Arabian Ministry of National Guard Health Affairs, King Saud Bin Abdulaziz University for Health Sciences and the Saudi Association for Public Health, aims to be the foremost scientific, peer-reviewed journal encompassing infection prevention and control, microbiology, infectious diseases, public health and the application of healthcare epidemiology to the evaluation of health outcomes. The point of view of the journal is that infection and public health are closely intertwined and that advances in one area will have positive consequences on the other. The journal will be useful to all health professionals who are partners in the management of patients with communicable diseases, keeping them up to date. The journal is proud to have an international and diverse editorial board that will assist and facilitate the publication of articles that reflect a global view on infection control and public health, as well as emphasizing our focus on supporting the needs of public health practitioners. It is our aim to improve healthcare by reducing risk of infection and related adverse outcomes by critical review, selection, and dissemination of new and relevant information in the field of infection control, public health and infectious diseases in all healthcare settings and the community.