南亚育龄个体（15-49岁）的孕产妇高血压疾病：一项全球疾病负担研究（1990-2021年）和未来预测

IF 2.1 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology Pub Date : 2025-03-07 DOI:10.1016/j.ejogrb.2025.03.012

Muhammed Shabil , Abhay M Gaidhane , Nasir Vadia , Soumya V Menon , Kattela Chennakesavulu , Rajashree Panigrahi , Ganesh Bushi , Diptismita Jena , Harish Kumar , Anju Rani , Sanjit Sah , Mahendra Singh , Khang Wen Goh , Lovely Jain

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引用次数: 0

摘要

背景：孕产妇高血压疾病（HDP）仍然是全球孕产妇和围产期发病率和死亡率的主要原因，特别是在医疗保健差距持续存在的南亚。本研究旨在分析1990年至2021年南亚孕产妇高血压疾病的趋势，利用全球疾病负担（GBD）研究的数据来评估医疗保健干预措施的有效性，并提供可行的建议。方法使用GBD 2021数据对孟加拉国、不丹、印度、尼泊尔和巴基斯坦进行回顾性分析。使用描述性统计和连接点回归分析流行率、发病率和孕产妇死亡率（MMR）等健康趋势。这种方法使我们能够确定研究期间的重大变化和趋势。结果该研究显示，该地区与孕产妇高血压疾病相关的患病率和MMR显著下降。在孟加拉国、不丹、印度和尼泊尔观察到显著的减少，而巴基斯坦的改善很小，表明持续的医疗挑战。该分析强调了重大的区域差异，特别是在巴基斯坦，该国报告的所有年龄组的患病率和MMR均较高。结论有针对性的保健干预可有效减轻南亚地区孕产妇高血压疾病负担。然而，巴基斯坦境内持续存在的差距突出表明，需要制定针对特定区域的战略，以解决医疗保健机会和质量方面的差距。加强卫生保健政策和改善干预覆盖范围可进一步减轻南亚HDP负担。

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Maternal hypertensive disorders among Individuals of reproductive age (15–49 Years) in South Asia: A global Burden of Disease study (1990–2021) with future Projections

Background

Maternal hypertensive disorders (HDP) remain a major contributor to maternal and perinatal morbidity and mortality worldwide, particularly in South Asia, where healthcare disparities persist.

Objective

This study aims to analyze trends in maternal hypertensive disorders across South Asia from 1990 to 2021, leveraging data from the Global Burden of Disease (GBD) study to evaluate the effectiveness of healthcare interventions and provide actionable recommendations.

Methods

We conducted a retrospective analysis using GBD 2021 data for Bangladesh, Bhutan, India, Nepal, and Pakistan. Health trends such as prevalence, incidence, and maternal mortality ratios (MMR) were analyzed using descriptive statistics and Join point regression. This approach allowed us to identify significant changes and trends over the studied period.

Results

The study revealed significant declines in the prevalence and MMR associated with maternal hypertensive disorders across the region. Notable reductions were observed in Bangladesh, Bhutan, India, and Nepal, while Pakistan showed minimal improvement, indicating ongoing healthcare challenges. The analysis underscores substantial regional disparities, particularly in Pakistan, which reported higher prevalence rates and MMR across all age groups.

Conclusions

The findings suggest that targeted healthcare interventions can effectively reduce the burden of maternal hypertensive disorders in South Asia. However, persistent disparities in Pakistan highlight the need for region-specific strategies to address gaps in healthcare access and quality. Strengthening healthcare policies and improving intervention coverage could further mitigate the burden of HDP in South Asia.

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来源期刊

European journal of obstetrics, gynecology, and reproductive biology 医学-妇产科学

CiteScore

4.60

自引率

3.80%

发文量

898

审稿时长

8.3 weeks

期刊介绍： The European Journal of Obstetrics & Gynecology and Reproductive Biology is the leading general clinical journal covering the continent. It publishes peer reviewed original research articles, as well as a wide range of news, book reviews, biographical, historical and educational articles and a lively correspondence section. Fields covered include obstetrics, prenatal diagnosis, maternal-fetal medicine, perinatology, general gynecology, gynecologic oncology, uro-gynecology, reproductive medicine, infertility, reproductive endocrinology, sexual medicine and reproductive ethics. The European Journal of Obstetrics & Gynecology and Reproductive Biology provides a forum for scientific and clinical professional communication in obstetrics and gynecology throughout Europe and the world.