Shuqi Wang , Yu Chang , Jingji Xu , Chenru Zhao , Yang Song , Mingchun Liu , Chunlian Tian
{"title":"表没食子儿茶素没食子酸酯、表没食子儿茶素没食子酸酯、表儿茶素没食子酸酯和表儿茶素体外抗炎、抗氧化和抗菌活性的比较研究","authors":"Shuqi Wang , Yu Chang , Jingji Xu , Chenru Zhao , Yang Song , Mingchun Liu , Chunlian Tian","doi":"10.1016/j.prmcm.2025.100599","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><div>catechin compounds are flavanols substance from various natural plants, and play a significant part in anti-inflammatory, anti-tumor, anti-oxidation, anti-bacteria and protecting the heart and brain organs and other pharmacological effects, and widely found in traditional Chinese medicine, such as <em>Kadsurae Caulis</em> and <em>Reynoutria japonica</em> Houtt.</div></div><div><h3>Methods</h3><div>this research was focused on the comparative study of anti-inflammatory, antioxidant and antibacterial activities of (-)-epigallocatechin gallate, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epicatechin <em>in vitro</em>.</div></div><div><h3>Results</h3><div>the results indicated that the antioxidant activities of the four catechin compounds improved with the concentration increasing from 0.5 to 32 μg/ml, and the antibacterial activities of four catechins were stronger against the gram-positive bacteria (<em>Staphylococcus aureus</em> and <em>Arcanobacterium pyogenes</em>) than the gram-negative bacteria (<em>Escherichia coli</em> and <em>Salmonella</em>). Moreover, 12.5, 25 and 50 μmol/l of (-)-epicatechin, (-)-epigallocatechin gallate, and 6.25, 12.5 and 25 µmol/L of (-)-epigallocatechin, (-)-epicatechin gallate could reduce the content of NO and phagocytosis.</div></div><div><h3>Discussion</h3><div>these results laid a foundation for the research and development of natural anti-inflammatory, antioxidant and antibacterial drugs in food and pharmaceutical industries.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100599"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparative study of anti-inflammatory, antioxidant and antibacterial activities of epigallocatechin gallate, epigallocatechin, epicatechin gallate and epicatechin in vitro\",\"authors\":\"Shuqi Wang , Yu Chang , Jingji Xu , Chenru Zhao , Yang Song , Mingchun Liu , Chunlian Tian\",\"doi\":\"10.1016/j.prmcm.2025.100599\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><div>catechin compounds are flavanols substance from various natural plants, and play a significant part in anti-inflammatory, anti-tumor, anti-oxidation, anti-bacteria and protecting the heart and brain organs and other pharmacological effects, and widely found in traditional Chinese medicine, such as <em>Kadsurae Caulis</em> and <em>Reynoutria japonica</em> Houtt.</div></div><div><h3>Methods</h3><div>this research was focused on the comparative study of anti-inflammatory, antioxidant and antibacterial activities of (-)-epigallocatechin gallate, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epicatechin <em>in vitro</em>.</div></div><div><h3>Results</h3><div>the results indicated that the antioxidant activities of the four catechin compounds improved with the concentration increasing from 0.5 to 32 μg/ml, and the antibacterial activities of four catechins were stronger against the gram-positive bacteria (<em>Staphylococcus aureus</em> and <em>Arcanobacterium pyogenes</em>) than the gram-negative bacteria (<em>Escherichia coli</em> and <em>Salmonella</em>). Moreover, 12.5, 25 and 50 μmol/l of (-)-epicatechin, (-)-epigallocatechin gallate, and 6.25, 12.5 and 25 µmol/L of (-)-epigallocatechin, (-)-epicatechin gallate could reduce the content of NO and phagocytosis.</div></div><div><h3>Discussion</h3><div>these results laid a foundation for the research and development of natural anti-inflammatory, antioxidant and antibacterial drugs in food and pharmaceutical industries.</div></div>\",\"PeriodicalId\":101013,\"journal\":{\"name\":\"Pharmacological Research - Modern Chinese Medicine\",\"volume\":\"15 \",\"pages\":\"Article 100599\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Modern Chinese Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667142525000284\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Modern Chinese Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667142525000284","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Comparative study of anti-inflammatory, antioxidant and antibacterial activities of epigallocatechin gallate, epigallocatechin, epicatechin gallate and epicatechin in vitro
Introduction
catechin compounds are flavanols substance from various natural plants, and play a significant part in anti-inflammatory, anti-tumor, anti-oxidation, anti-bacteria and protecting the heart and brain organs and other pharmacological effects, and widely found in traditional Chinese medicine, such as Kadsurae Caulis and Reynoutria japonica Houtt.
Methods
this research was focused on the comparative study of anti-inflammatory, antioxidant and antibacterial activities of (-)-epigallocatechin gallate, (-)-epigallocatechin, (-)-epicatechin gallate and (-)-epicatechin in vitro.
Results
the results indicated that the antioxidant activities of the four catechin compounds improved with the concentration increasing from 0.5 to 32 μg/ml, and the antibacterial activities of four catechins were stronger against the gram-positive bacteria (Staphylococcus aureus and Arcanobacterium pyogenes) than the gram-negative bacteria (Escherichia coli and Salmonella). Moreover, 12.5, 25 and 50 μmol/l of (-)-epicatechin, (-)-epigallocatechin gallate, and 6.25, 12.5 and 25 µmol/L of (-)-epigallocatechin, (-)-epicatechin gallate could reduce the content of NO and phagocytosis.
Discussion
these results laid a foundation for the research and development of natural anti-inflammatory, antioxidant and antibacterial drugs in food and pharmaceutical industries.
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