十钨酸盐光催化合成3,3-二取代氧吲哚的级联C(sp3)-氢键功能化/环化反应

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-03-11 DOI:10.1016/j.tet.2025.134578

Xianhe Fang , Jiaxing Lv , Shuxin Yang , Mingyu Ma , Runzhe Yang , Yi Bi

引用次数: 0

摘要

本文描述了一个级联C(sp3)-H键功能化/环化反应，用于合成3,3-二取代氧吲哚。在近紫外光照射下，十钨酸盐阴离子催化反应。脂族C(sp3)−H键的功能化通过这种催化反应有效地发生。此外，所选产品对lps诱导的巨噬细胞一氧化氮释放有抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cascade C(sp3)-H bond functionalization/cyclization reaction for the synthesis of 3,3-disubstituted oxindoles by decatungstate photocatalysis

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Cascade C(sp3)-H bond functionalization/cyclization reaction for the synthesis of 3,3-disubstituted oxindoles by decatungstate photocatalysis

Herein, we describe a cascade C(sp³)-H bond functionalization/cyclization reaction for the synthesis of 3,3-disubstituted oxindoles. The reaction is catalyzed by decatungstate anion under near-ultraviolet light irradiation. Functionalization of aliphatic C(sp³)−H bonds occurs efficiently through this catalytic reaction. Furthermore, the selected products exhibited inhibitory effects on LPS-induced macrophage nitric oxide release.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.