海洋天然产物氨酰胺B新型衍生物的设计、合成及生物学评价

IF 3.8 1区农林科学 Q1 AGRONOMY

Pest Management Science Pub Date : 2025-03-13 DOI:10.1002/ps.8748

Ming-jun Zhang, Ming-xu Li, Ai-dang Lu, Hong-ying Tang, Zheng-hong Zhou, Qing-min Wang, Zi-wen Wang

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引用次数: 0

摘要

由植物病毒和病原体引起的植物病害严重影响作物产量和品质，防控难度极大，对人类健康构成严重威胁。海洋生物碱结构新颖，生物活性丰富，是开发新型农药的重要来源。本研究选择氨酰胺类生物碱为亲本结构。合成了一系列以氯化吡咯[4,3,2-de]喹啉为基础的衍生物，并对其抗病毒和杀真菌活性进行了评价。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Design, synthesis, and biological evaluation of novel derivatives of marine natural product ammosamide B

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Design, synthesis, and biological evaluation of novel derivatives of marine natural product ammosamide B

Plant diseases caused by plant viruses and pathogens seriously affect crop yield and quality, making prevention and control extremely difficult and posing a serious threat to human health. Marine alkaloids have novel structures and diverse biological activities, which are an important source of the development of new pesticides. In this work, ammosamide alkaloids were selected as the parent structure. A series of derivatives based on the chlorinated pyrrolo[4,3,2-de]quinoline were synthesized and evaluated for their antiviral and fungicidal activities.

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来源期刊

Pest Management Science 农林科学-昆虫学

CiteScore

7.90

自引率

9.80%

发文量

553

审稿时长

4.8 months

期刊介绍： Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.