[房间隔缺损经皮闭合术后高敏感性心肌肌钙蛋白T升高的决定因素]。

Alejandro E Contreras, Alejandro R Peirone, Ernesto Juaneda, Víctor Defagó, Eduardo Cuestas
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引用次数: 0

摘要

目的:目的是确定经皮心房间隔缺损(ASD)主动脉缘缺损闭合术后超敏肌钙蛋白T (hs-cTnT)升高与标准和特定干预操作的关系。方法:测量基线hs-cTnT,并在手术后6小时重复。为了确定自变量与因变量(hs-cTnT的变化)的影响,使用了广义线性混合模型。结果:总队列包括106例患者。中位年龄为8岁,22例(21%)患者年龄大于18岁。术前hs-TnT为3.7 pg/ml,干预结束后6小时hs-TnT为72.5 pg/ml。主动脉边缘充足与主动脉边缘不足患者6小时hs-TnT相似。广义线性混合模型显示hs-cTnT变化与ASD直径直接相关(β: 2.8;CI: 0.8 ~ 4.9;P < 0.01)和透视时间(β: 2.7;CI: 0.6 ~ 4.7;p < 0.01), hs-cTnT变化与患者体重呈负相关(β: -0.7;CI: -1.1 ~ -0.3;P < 0.01)。结论:经皮ASD治疗后hs-cTnT的升高与ASD直径、透视时间呈正相关,与患者体重成反比。主动脉边缘缺损与hs-cTnT升高无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Determinants of elevation of high sensitivity cardiac troponin T after an atrial septal defect percutaneous closure].

Objectives: The aim was to determine the relationship between the elevation of ultrasensitive troponin T (hs-cTnT) after percutaneous atrial septal defect (ASD) closure with deficient aortic rim and with standard and specific maneuvers of the intervention.

Method: Baseline hs-cTnT was measured and repeated 6 hours after the procedure. To determine the influence of independent variables with the dependent variable (change in hs-cTnT), a generalized linear mixed model was used.

Results: The total cohort consisted in 106 patients. The median age was 8 years, and 22 patients (21%) were older than 18 years. The hs-TnT before the procedure was 3.7 pg/ml and 6 hours after the intervention was finalized was 72.5 pg/ml. The hs-TnT at 6 hours was similar in patients with sufficient vs. deficient aortic rim. A generalized linear mixed model demonstrated a direct relationship between hs-cTnT change and ASD diameter (β: 2.8; CI: 0.8 to 4.9; p < 0.01) and fluoroscopy time (β: 2.7; CI: 0.6 to 4.7; p < 0.01) and an inverse relationship between hs-cTnT change and patient weight (β: -0.7; CI: -1.1 to -0.3; p < 0.01).

Conclusions: The increase in hs-cTnT after percutaneous ASD treatment was directly related to ASD diameter and the fluoroscopy time and inversely to the patient weight. Aortic rim deficit was not associated with elevation of hs-cTnT.

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