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IF 2 4区医学 Q3 NUTRITION & DIETETICS

Nutrition and Cancer-An International Journal Pub Date : 2025-03-12 DOI:10.1080/01635581.2025.2474262

Elvis Obomanu, Phuuwadith Wattanachayakul, Colton Jones, Karecia Byfield, Akshay Ratnani, Ryan Mayo

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引用次数: 0

摘要

背景：乳腺癌患者因化疗或癌症本身的影响而面临急性失代偿性心力衰竭（ADHF）和蛋白质能量营养不良（PEM）的风险。目前还没有关于 PEM 对因 ADHF 住院的乳腺癌患者影响的研究。本研究旨在评估 PEM 对因 ADHF 住院的乳腺癌患者的影响：我们的研究利用 2020 年美国全国住院患者样本（NIS），对 18 岁及以上的乳腺癌患者进行了分析。多变量逻辑和线性回归分析确定了各种结果的几率比例。主要结果是因 ADHF 住院患者的住院死亡率，以是否存在 PEM 为依据，次要结果包括心源性休克、贫血和住院总费用：共发现 35555 (30,555) 名患者，主要为女性（99%）和白种人（71.4%）。其中，6.07%的患者被诊断为并发 PEM。PEM 与较高的院内死亡风险（aOR 2.61）、较高的心源性休克（aOR 3.17）、贫血（aOR 1.43）、较长的住院时间（b 2.09）和较高的住院费用（平均 28,285 美元）相关：研究结果表明，在因 ADHF 入院的乳腺癌患者中，合并 PEM 与院内死亡率、贫血、心源性休克、住院时间延长和住院总费用增加的风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Impact of Protein Energy Malnutrition on Breast Cancer Patients Hospitalized with Acute Decompensated Heart Failure: Insight from NIS Database 2020.

Background: Breast cancer patients are at risk of acute decompensated heart failure (ADHF) and protein-energy malnutrition (PEM) due to chemoradiation effects or cancer itself. There are no existing studies on the impact of PEM on breast cancer patients hospitalized for ADHF. This study aims to evaluate the effects of PEM on breast cancer patients admitted for ADHF.

Methods: Using the 2020 US National Inpatient Sample (NIS), our study analyzed breast cancer patients aged 18 and older. A multivariate logistic and linear regression analysis determined the odds ratio for various outcomes. The primary outcome was inpatient mortality among patients hospitalized for ADHF based on the presence or absence of PEM, while secondary outcomes included cardiogenic shock, anemia, and total hospital charges.

Results: Thirty thousand five hundred and fifty-five (30,555) patients were identified, predominantly female (99%) and Caucasian (71.4%). Among them, 6.07% were diagnosed with concurrent PEM. PEM was associated with higher in-hospital mortality risk (aOR 2.61), increased cardiogenic shock (aOR 3.17), anemia (aOR 1.43), more extended hospital stays (b 2.09), and higher hospital charges (average $28,285).

Conclusions: The findings indicate that comorbid PEM is associated with increased risks of in-hospital mortality, anemia, cardiogenic shock, prolonged hospital stays and increased overall hospital costs among breast cancer patients admitted for ADHF.

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.