评估年轻黑人女性三阴性乳腺癌分子亚型的人群特异性模式。

IF 7.6 2区医学 Q1 ONCOLOGY

NPJ Breast Cancer Pub Date : 2025-03-11 DOI:10.1038/s41523-025-00731-0

Padma Sheila Rajagopal, Sonya Reid, Run Fan, Lindsay Venton, Anne Weidner, Mya L Roberson, Susan Vadaparampil, Xuefeng Wang, Sean Yoder, Marilin Rosa, Melinda Sanders, Paula Gonzalez-Ericsson, Jibril Hirbo, Jennifer G Whisenant, Jennifer Pietenpol, Fei Ye, Tuya Pal, Brian D Lehmann

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引用次数: 0

摘要

我们确定了三阴性乳腺癌（TNBC）亚型、遗传血统和免疫特征，研究对象是年龄在50岁或以下、自我报告为TNBC的黑人女性。在104例肿瘤中，34.6%为基底样1 (BL1)， 17.3%为基底样2 (BL2)， 9.6%为腔内雄激素受体（LAR）， 26.9%为间充质(M)， 11.5%为无亚型（UNS）。亚型与欧洲人或东亚人相似，LAR较少（9.6%比14.6-24.4%），UNS较多（11.5%比0-7.5%）。西非血统的“高”比例与更多的LAR（14.9%对4.9%）和更少的M（25.5%对34.2%）相关。在包括分期、西非血统、BMI和til在内的多变量模型中，M表现出免疫活性降低，并与较差的总生存率轻微相关，值得未来的研究。我们的研究是迄今为止在年轻黑人女性中最大的TNBC亚型研究。这些结果加强了TNBC亚型在人群中的应用以及作为预后生物标志物的潜在用途。

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Population-specific patterns in assessing molecular subtypes of young black females with triple-negative breast cancer.

We determined triple-negative breast cancer (TNBC) subtypes, genetic ancestry, and immune features in a cohort of self-reported Black females with TNBC diagnosed at or below age 50. Among 104 tumors, 34.6% were basal-like 1 (BL1), 17.3% basal-like 2 (BL2), 9.6% luminal androgen receptor (LAR), 26.9% mesenchymal (M), and 11.5% unsubtyped (UNS). Subtypes resembled those seen in Europeans or East Asians, with less LAR (9.6% vs. 14.6-24.4%) and more UNS (11.5% vs. 0-7.5%). "High" proportion of West African ancestry was associated with more LAR (14.9% vs. 4.9%) and less M (25.5% vs. 34.2%). M demonstrated reduced immune activity and was marginally associated with worse overall survival in a multivariate model including stage, West African ancestry, BMI, and TILs, meriting future research. Our study is the largest to date of TNBC subtypes in young Black females. These results reinforce TNBC subtypes' application across populations and potential use as a prognostic biomarker.

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来源期刊

NPJ Breast Cancer Medicine-Pharmacology (medical)

CiteScore

10.10

自引率

1.70%

发文量

122

审稿时长

9 weeks

期刊介绍： npj Breast Cancer publishes original research articles, reviews, brief correspondence, meeting reports, editorial summaries and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas, or the framing of new questions that need to be solved. Featured topics of the journal include imaging, immunotherapy, molecular classification of disease, mechanism-based therapies largely targeting signal transduction pathways, carcinogenesis including hereditary susceptibility and molecular epidemiology, survivorship issues including long-term toxicities of treatment and secondary neoplasm occurrence, the biophysics of cancer, mechanisms of metastasis and their perturbation, and studies of the tumor microenvironment.