脆弱但方便:设计一种算法作为可卡因成瘾药物治疗的新方法。

IF 0.6 4区 医学 Q4 CLINICAL NEUROLOGY
Sebastian Karl Maximilian Fischer, Jochen Mutschler
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引用次数: 0

摘要

可卡因成瘾不仅对个人而且对社会都是一种毁灭性的疾病。由于全世界可卡因消费量的迅速增加,可卡因及其有害的精神和身体后果日益成为成瘾医学的主要焦点。不幸的是,治疗可卡因成瘾的进展跟不上对有效、快速、容易获得和负担得起的治疗方法的激增需求。社会心理和心理治疗措施仍然是治疗的主要手段,但许多患者无法获得或从这些治疗方式中充分受益。迄今为止,还没有一种药物疗法被批准或被证明对可卡因成瘾始终有效。尽管如此,从大量的研究中可以提取出相当数量的有希望的候选物质,并且有足够的证据证明许多患者可能从这些物质中的至少一种中受益。我们对文献进行了全面的分析,并贡献了自己的研究成果,以便将临床相关的发现整合到一个算法中,使临床医生能够在日常实践中使用当前的知识状态。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Flimsy but handy: Devising an algorithm as a novel approach to the pharmacotherapy of cocaine addiction.

Cocaine addiction is a devastating disorder, not only for the individual but also for society. Due to the rapid increase in cocaine consumption worldwide, cocaine and its deleterious psychiatric and physical consequences have increasingly become a major focus of addiction medicine. Unfortunately, advances in the treatment of cocaine addiction cannot keep pace with the surging demand for effective, fast-acting, readily available and affordable therapies. Psychosocial and psychotherapeutic measures are still the mainstay of therapy, but many patients do not have access to or benefit sufficiently from these treatment modalities. To date, there is no pharmacotherapy that has been approved or shown to be consistently effective for cocaine addiction. Nonetheless, a fair number of promising candidate substances can be extracted from a large pool of studies and there exists enough evidence to justify the assumption that many patients are likely to benefit from at least one of these substances. We have thoroughly analyzed the literature and contributed our own research results in order to integrate clinically relevant findings into an algorithm that enables the clinician to make the current state of knowledge usable in routine practice.

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来源期刊
CiteScore
1.10
自引率
16.70%
发文量
139
审稿时长
6-12 weeks
期刊介绍: Fundiertes Wissen für den Berufsalltag Relevante Originalarbeiten Informative Übersichten zu wichtigen Themen Fortbildungsteil mit Zertifizierung – 36 CME-Punkte pro Jahr Interessante Kasuistiken Referiert & kommentiert: Internationale Studien Aktuelles zu Begutachtung und Neurobiologie International gelistet und häufig zitiert
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