静态和动态屏气时的心血管和脑血流动力学。

IF 2.8 3区 医学 Q2 PHYSIOLOGY
European Journal of Applied Physiology Pub Date : 2025-07-01 Epub Date: 2025-03-12 DOI:10.1007/s00421-025-05742-0
Jérémie Allinger, Guillaume Costalat, Catherine Chiron, Marion Nouhliane, Gaelle Mediouni, Emilie Carré, Frédéric Lemaître
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引用次数: 0

摘要

目的:研究中度训练的休闲屏气潜水员(BHDs)在静态(SBH)和动态(DYNBH)屏气(BH)期间潜水反应引起的心血管和脑血流动力学的变化。方法:19例BHDs(42.9±7.8年,5.7±2.5年)参与研究。通过动脉容积钳、经颅多普勒超声和近红外光谱连续跟踪单次SBH和DYNBH期间的心血管和脑血流动力学以及肌肉和前额皮质氧合情况。此外,在bh前后测量神经元特异性烯醇化酶(NSE)以评估潜在的神经元应激。结果:在BH结束时,两种情况下的潜水反应表现相似,其特征是心动过缓反应(SBH: - 14±6%,p BH: - 13±18%,p BH: + 127±46%,p BH: + 116±110%,p BH(+ 139±17%,p BH(+ 109±23%),p BH与SBH(+ 350±106% vs + 128±27%,p BH和DYNBH)相比。结论:由于脑血流速度的增加相对减弱,DYNBH比SBH造成更大的供氧量和前额叶耗氧量的不平衡。然而,NSE水平与基线值保持不变,表明两种情况下均未发生急性神经元损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiovascular and cerebral hemodynamics during static and dynamic breath-holding.

Purpose: The study investigated the changes in cardiovascular and cerebral hemodynamics elicited by the diving response during static (SBH) and dynamic (DYNBH) breath-holding (BH) in moderately trained recreational breath-hold divers (BHDs).

Methods: Nineteen BHDs (42.9 ± 7.8 years, 5.7 ± 2.5 years of breath-hold practice) participated in the study. Cardiovascular and cerebral hemodynamics, along with muscle and pre-frontal cortex oxygenation, were continuously tracked throughout a single SBH and DYNBH by means of arterial volume clamp, transcranial Doppler ultrasound, and near-infrared spectroscopy. In addition, neuron-specific enolase (NSE) was measured pre- and post-BH to evaluate potential neuronal stress.

Results: At the end of BH, the manifestations of the diving response were similar in both conditions, characterized by a bradycardic response (SBH: - 14 ± 6%, p < 0.05; DYNBH: - 13 ± 18%, p < 0.05) and an increase in total peripheral resistance (SBH: + 127 ± 46%, p < 0.05; DYNBH: + 116 ± 110%, p < 0.05). Mean middle cerebral artery blood velocity increased significantly more during SBH (+ 139 ± 17%, p < 0.05) than DYNBH (+ 109 ± 23%, p < 0.05). Relative changes in pre-frontal cortex deoxygenated hemoglobin were higher during DYNBH compared to SBH (+ 350 ± 106% vs. + 128 ± 27%, p < 0.05). NSE levels did not change pre- and post- SBH and DYNBH.

Conclusion: Due to relatively attenuated increase in cerebral blood velocity, DYNBH resulted in a greater imbalance between oxygen supply and pre-frontal oxygen consumption than SBH. However, NSE levels remained unchanged from baseline values, suggesting that no acute neuronal damage occurred in either condition.

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来源期刊
CiteScore
6.00
自引率
6.70%
发文量
227
审稿时长
3 months
期刊介绍: The European Journal of Applied Physiology (EJAP) aims to promote mechanistic advances in human integrative and translational physiology. Physiology is viewed broadly, having overlapping context with related disciplines such as biomechanics, biochemistry, endocrinology, ergonomics, immunology, motor control, and nutrition. EJAP welcomes studies dealing with physical exercise, training and performance. Studies addressing physiological mechanisms are preferred over descriptive studies. Papers dealing with animal models or pathophysiological conditions are not excluded from consideration, but must be clearly relevant to human physiology.
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