膀胱癌的代谢景观。

IF 2.8 4区 医学 Q2 ONCOLOGY
Current Opinion in Oncology Pub Date : 2025-05-01 Epub Date: 2025-03-11 DOI:10.1097/CCO.0000000000001137
Syrus Razavi, Amir Khan, De-Xue Fu, Dirk Mayer, David McConkey, Nagireddy Putluri, M Minhaj Siddiqui
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引用次数: 0

摘要

综述目的:本文回顾了膀胱癌(BC)相关代谢途径的现有文献,并从四个方面进行了研究:(1)诊断,(2)癌症分类(分期和分级),(3)跟踪,(4)治疗。最近的发现:对相关数据库的系统搜索确定了符合预定义纳入标准的研究。多种代谢途径被发现与BC具有重要的生物学和临床相关性,特别强调氨基酸(AA)、脂质、核酸(NA)和生物能量途径。最近的研究已经阐明了代谢组学在诊断BC、疾病分期和分级、监测进展或复发以及告知治疗策略方面的效用。具体来说,在关注BC诊断的研究中,脂肪酸被观察到上调多达90倍,同时AA代谢物也上调。代谢物如AA、脂质和醛类显示出作为BC诊断生物标志物的潜力。NA代谢物在监测术后BC状态方面特别有效。此外,脂质、生物能量和AA途径的代谢物在预测肿瘤细胞对化疗的敏感性方面显示出效用。摘要:广泛的代谢途径和代谢物为BC的诊断、分期、监测和治疗提供了巨大的应用潜力。这些发现强调了代谢组学作为改善BC管理和患者预后的有价值工具的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic landscape in bladder cancer.

Purpose of review: This review examines the existing literature on metabolic pathways associated with bladder cancer (BC) and investigates four domains: (1) diagnoses, (2) cancer classification (staging & grading), (3) tracking, and (4) treatment.

Recent findings: A systematic search of relevant databases identified studies meeting predefined inclusion criteria. A diverse array of metabolic pathways was found to hold significant biological and clinical relevance to BC, with particular emphasis on amino acid (AA), lipid, nucleic acid (NA), and bioenergetic pathways. Recent studies have elucidated utilities for metabolomics in diagnosis of BC, staging and grading the disease, monitoring progression or recurrence, and informing treatment strategies. Specifically, fatty acids were observed to be upregulated by as much as 90-fold in studies focused on BC diagnosis, alongside the upregulation of AA metabolites. Metabolites such as AA, lipids, and aldehydes showed potential as diagnostic biomarkers for BC. NA metabolites were particularly effective in monitoring BC status postsurgical resection. Furthermore, metabolites from lipid, bioenergetic, and AA pathways demonstrated utility in predicting tumor cell sensitivity to chemotherapy.

Summary: A broad spectrum of metabolic pathways and metabolites offers significant potential for applications in the diagnosis, staging, monitoring, and treatment of BC. These findings underscore the promise of metabolomics as a valuable tool in improving BC management and patient outcomes.

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来源期刊
Current Opinion in Oncology
Current Opinion in Oncology 医学-肿瘤学
CiteScore
6.10
自引率
2.90%
发文量
130
审稿时长
4-8 weeks
期刊介绍: With its easy-to-digest reviews on important advances in world literature, Current Opinion in Oncology offers expert evaluation on a wide range of topics from sixteen key disciplines including sarcomas, cancer biology, melanoma and endocrine tumors. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by annotated references detailing the merits of the most important papers.
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