前列腺癌中的多胺代谢。

IF 2.8 4区 医学 Q2 ONCOLOGY
Current Opinion in Oncology Pub Date : 2025-05-01 Epub Date: 2025-02-20 DOI:10.1097/CCO.0000000000001134
Laura A Sena
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引用次数: 0

摘要

综述的目的:正常和恶性前列腺的多胺新合成率高。本文综述了多胺代谢如何调节前列腺癌的发生和发展。最近的研究发现:雄激素受体(AR)在正常前列腺中建立了一个代谢程序来驱动强大的多胺合成。在恶性转化过程中,这种ar驱动的代谢程序持续存在,并通过原癌基因MYC和/或PI3K信号的改变优化成癌。通过考虑多胺在正常前列腺中的功能,可以更深入地了解多胺在前列腺癌中的功能。摘要:最近的研究结果支持正在进行的多胺在前列腺癌发生和发展中的作用的研究,并表明靶向多胺代谢仍然是预防和治疗前列腺癌的一种有前途的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Polyamine metabolism in prostate cancer.

Purpose of review: Normal and malignant prostate engage in high rates of de novo polyamine synthesis. This review considers how polyamine metabolism regulates prostate cancer initiation and progression.

Recent findings: The androgen receptor (AR) establishes a metabolic program to drive robust polyamine synthesis in the normal prostate. Upon malignant transformation, this AR-driven metabolic program persists and is optimized for oncogenesis by the proto-oncogene MYC and/or alterations to PI3K signaling. A deeper understanding of the function of polyamines in prostate cancer may be obtained by considering their function in the normal prostate.

Summary: Recent findings support ongoing research into the role of polyamines in driving prostate cancer initiation and progression and suggest targeting polyamine metabolism remains a promising therapeutic strategy for prevention and treatment of prostate cancer.

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来源期刊
Current Opinion in Oncology
Current Opinion in Oncology 医学-肿瘤学
CiteScore
6.10
自引率
2.90%
发文量
130
审稿时长
4-8 weeks
期刊介绍: With its easy-to-digest reviews on important advances in world literature, Current Opinion in Oncology offers expert evaluation on a wide range of topics from sixteen key disciplines including sarcomas, cancer biology, melanoma and endocrine tumors. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by annotated references detailing the merits of the most important papers.
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