Lisa M McKenzie, William B Allshouse, David R Johnson, Christopher C DeVoe, Myles Cockburn, Debashis Ghosh
{"title":"科罗拉多州石油和天然气开发暴露与儿童白血病风险：一项基于人群的病例对照研究","authors":"Lisa M McKenzie, William B Allshouse, David R Johnson, Christopher C DeVoe, Myles Cockburn, Debashis Ghosh","doi":"10.1158/1055-9965.EPI-24-1583","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Children living in upstream oil and natural gas (O&G) areas may be exposed to leukemogens and at increased risk for acute lymphocytic leukemia (ALL).</p><p><strong>Methods: </strong>We conducted a case-control study of children born in Colorado between 1992 and 2019. We matched 451 children diagnosed with ALL at age 2-9 years starting in 2002 to 2706 controls on birth month/year and Hispanic ethnicity. We estimated upstream O&G activity intensities from conception through a 10-year latency with our intensity adjusted inverse distance weighted (IA-IDW) model. We applied logistic regression models adjusted for confounders to evaluate associations between ALL and IA-IDW.</p><p><strong>Results: </strong>For children within 5 km of an O&G well site, we observed a 62% (OR= 1.62, 95% CL:0.964, 2.62), 84% (OR = 1.84, 95% CL: 1.35 -2.48) and 100% (OR = 2.00, 95% CL: 1.14 -3.37) increase in ALL risk for low, medium, and high IA-IDW groups, compared to the referent group. Within 13 km, we observed a 59% (OR= 1.59, 95% CL:1.03, 2.37), 40% (OR = 1.40, 95% CL: 1.09 -1.80) and 164% (OR = 2.64, 95% CL: 1.80 -3.86) increase in ALL risk for low, medium, and high IA-IDW groups.</p><p><strong>Conclusions: </strong>Colorado's children living within 13 km of O&G well sites are at increased risk for ALL, with children within 5 km bearing the greatest risk. Current setbacks between O&G well sites and residences may not be sufficient to protect the health of these children.</p><p><strong>Impact: </strong>Our results can be applied to policies to reduce childhood leukemogen exposures.</p>","PeriodicalId":9458,"journal":{"name":"Cancer Epidemiology Biomarkers & Prevention","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exposures from oil and gas development and childhood leukemia risk in Colorado: A population-based case-control study.\",\"authors\":\"Lisa M McKenzie, William B Allshouse, David R Johnson, Christopher C DeVoe, Myles Cockburn, Debashis Ghosh\",\"doi\":\"10.1158/1055-9965.EPI-24-1583\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Children living in upstream oil and natural gas (O&G) areas may be exposed to leukemogens and at increased risk for acute lymphocytic leukemia (ALL).</p><p><strong>Methods: </strong>We conducted a case-control study of children born in Colorado between 1992 and 2019. We matched 451 children diagnosed with ALL at age 2-9 years starting in 2002 to 2706 controls on birth month/year and Hispanic ethnicity. We estimated upstream O&G activity intensities from conception through a 10-year latency with our intensity adjusted inverse distance weighted (IA-IDW) model. We applied logistic regression models adjusted for confounders to evaluate associations between ALL and IA-IDW.</p><p><strong>Results: </strong>For children within 5 km of an O&G well site, we observed a 62% (OR= 1.62, 95% CL:0.964, 2.62), 84% (OR = 1.84, 95% CL: 1.35 -2.48) and 100% (OR = 2.00, 95% CL: 1.14 -3.37) increase in ALL risk for low, medium, and high IA-IDW groups, compared to the referent group. Within 13 km, we observed a 59% (OR= 1.59, 95% CL:1.03, 2.37), 40% (OR = 1.40, 95% CL: 1.09 -1.80) and 164% (OR = 2.64, 95% CL: 1.80 -3.86) increase in ALL risk for low, medium, and high IA-IDW groups.</p><p><strong>Conclusions: </strong>Colorado's children living within 13 km of O&G well sites are at increased risk for ALL, with children within 5 km bearing the greatest risk. Current setbacks between O&G well sites and residences may not be sufficient to protect the health of these children.</p><p><strong>Impact: </strong>Our results can be applied to policies to reduce childhood leukemogen exposures.</p>\",\"PeriodicalId\":9458,\"journal\":{\"name\":\"Cancer Epidemiology Biomarkers & Prevention\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-03-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer Epidemiology Biomarkers & Prevention\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1158/1055-9965.EPI-24-1583\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Epidemiology Biomarkers & Prevention","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1158/1055-9965.EPI-24-1583","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
Exposures from oil and gas development and childhood leukemia risk in Colorado: A population-based case-control study.
Background: Children living in upstream oil and natural gas (O&G) areas may be exposed to leukemogens and at increased risk for acute lymphocytic leukemia (ALL).
Methods: We conducted a case-control study of children born in Colorado between 1992 and 2019. We matched 451 children diagnosed with ALL at age 2-9 years starting in 2002 to 2706 controls on birth month/year and Hispanic ethnicity. We estimated upstream O&G activity intensities from conception through a 10-year latency with our intensity adjusted inverse distance weighted (IA-IDW) model. We applied logistic regression models adjusted for confounders to evaluate associations between ALL and IA-IDW.
Results: For children within 5 km of an O&G well site, we observed a 62% (OR= 1.62, 95% CL:0.964, 2.62), 84% (OR = 1.84, 95% CL: 1.35 -2.48) and 100% (OR = 2.00, 95% CL: 1.14 -3.37) increase in ALL risk for low, medium, and high IA-IDW groups, compared to the referent group. Within 13 km, we observed a 59% (OR= 1.59, 95% CL:1.03, 2.37), 40% (OR = 1.40, 95% CL: 1.09 -1.80) and 164% (OR = 2.64, 95% CL: 1.80 -3.86) increase in ALL risk for low, medium, and high IA-IDW groups.
Conclusions: Colorado's children living within 13 km of O&G well sites are at increased risk for ALL, with children within 5 km bearing the greatest risk. Current setbacks between O&G well sites and residences may not be sufficient to protect the health of these children.
Impact: Our results can be applied to policies to reduce childhood leukemogen exposures.
期刊介绍：
Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.
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