伊朗德黑兰和加兹温市医院分离的志贺氏菌临床菌株的抗生素耐药性和分子特征

IF 1.6 Q2 MULTIDISCIPLINARY SCIENCES

BMC Research Notes Pub Date : 2025-03-11 DOI:10.1186/s13104-025-07113-6

Termeh Raoufian, Babak Pakbin, Akram Sadat Tabatabaee Bafroee

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引用次数: 0

摘要

目的：调查2003 - 2023年加兹温市和德黑兰市志贺氏菌的流行病学和遗传变化，重点分析分离株的耐药性。本研究基于从患者粪便中分离的80株志贺氏菌的分析。结果：采用脉冲场凝胶电泳（PFGE）作为主要分型方法，将分离物分为13个不同的簇，揭示了一个持续20多年的优势模式。这种持续性可能归因于卫生条件差、个人接触、移民和抗生素耐药性等因素。遗传分析表明，在近20年的时间里，分离株的克隆扩增。值得注意的是，对阿莫西林的耐药性最高，有几株菌株表现出多药耐药。

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Antibiotic resistance and molecular characterization of clinical Shigella spp. isolated from hospitals located in Tehran and Qazvin cities, Iran.

Objective: This research aims to investigate the epidemiology and genetic changes of Shigella species in the cities of Qazvin and Tehran from 2003 to 2023, with a focus on assessing antibiotic resistance among the isolates. This study is based on the analysis of 80 Shigella isolates, which were obtained from patients' feces.

Results: Using pulsed-field gel electrophoresis (PFGE) as the primary typing method, the isolates were classified into 13 distinct clusters, revealing a dominant pattern that has persisted for over twenty years. This persistence may be attributed to factors such as poor hygiene, personal contact, immigration, and antibiotic resistance. Genetic analysis indicated clonal expansion among the isolates over the two-decade period. Notably, the highest resistance was observed against amoxicillin, with several isolates exhibiting multidrug resistance.

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来源期刊

BMC Research Notes Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

3.60

自引率

0.00%

发文量

363

审稿时长

15 weeks

期刊介绍： BMC Research Notes publishes scientifically valid research outputs that cannot be considered as full research or methodology articles. We support the research community across all scientific and clinical disciplines by providing an open access forum for sharing data and useful information; this includes, but is not limited to, updates to previous work, additions to established methods, short publications, null results, research proposals and data management plans.