MLLT3通过抑制HMGB1核进入和MAGEA1 M5C修饰调控黑色素瘤的发生和进展（add . Sci. 10/2025）

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-03-13 DOI:10.1002/advs.202570062

Yaling Li, Hong Liu, Jingyi Li, Chang Fu, Bin Jiang, Bancheng Chen, Yanfen Zou, Bo Yu, Bing Song

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引用次数: 0

摘要

MLLT3是一种调控黑色素瘤干性和进展的转录因子。在细胞质中，MLLT3与YBX1紧密结合，抑制MAGEA1的m5C读取，从而抑制MAGEA1 mRNA的稳定性。这直接导致P53的转录激活，进而抑制黑色素瘤细胞的干性、增殖和转移。更多的细节可以在李亚玲，余波，宋冰和同事的文章2408529中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

MLLT3 Regulates Melanoma Stemness and Progression by Inhibiting HMGB1 Nuclear Entry and MAGEA1 M5C Modification (Adv. Sci. 10/2025)

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MLLT3 Regulates Melanoma Stemness and Progression by Inhibiting HMGB1 Nuclear Entry and MAGEA1 M5C Modification (Adv. Sci. 10/2025)

MLLT3 Regulates Melanoma Stemness

MLLT3 is a transcription factor that regulates the stemness and progression of melanoma. In the cytoplasm, MLLT3 tightly binds to YBX1, inhibiting the m5C reading of MAGEA1, thereby suppressing the mRNA stability of MAGEA1. This directly leads to the transcriptional activation of P53, which in turn suppresses the stemness, proliferation, and metastasis of melanoma cells. More details can be found in article number 2408529 by Yaling Li, Bo Yu, Bing Song, and co-workers.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.