应用田口灰关联分析优化3D打印Voronoi微结构骨支架

Q1 Computer Science

Bioprinting Pub Date : 2025-03-08 DOI:10.1016/j.bprint.2025.e00402

Rochmad Winarso , Sugeng Slamet , Rianto Wibowo , Sigit Arrohman , Akhmad Zidni Hudaya , Rifky Ismail , Jamari , Athanasius Priharyoto Bayuseno

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引用次数: 0

摘要

3D打印骨支架是骨组织工程的一种前沿方法，可能解决临界尺寸的骨缺陷挑战。虽然目前的研究主要集中在打印中的拉伸参数，但压缩参数往往被忽视，尽管它们在支架性能中起着至关重要的作用。本研究旨在通过定制打印参数，优化Voronoi微结构骨支架的力学性能。利用田口法和灰色关联分析（GRA），确定了试件组之间弹性模量和抗压强度等力学参数的显著变化。打印层高、线宽、打印温度和打印速度等关键打印因素对3D打印中使用的聚乳酸（PLA）的抗压强度和弹性模量具有关键影响。这项研究展示了将Taguchi-GRA方法与Voronoi微架构相结合以实现卓越机械性能的新颖性。其中，最佳设置层高0.0625 mm，线宽0.25 mm，打印温度215℃，打印速度55 mm/s，可获得抗压强度和弹性模量增强的支架，满足骨再生的生物力学要求。有必要进一步研究，以建立全面的指导方针，以实现3d打印PLA部件的一致机械性能，从而提高骨支架应用的有效性和可靠性。本研究结果为规范骨支架3D打印方案提供了基础，弥合了实验设计与临床应用之间的差距。通过解决关键瓶颈和引入创新的解决方案，本研究有助于推进骨组织工程领域和改善再生医学的成果。骨组织工程患者预后。

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Optimization of 3D printed Voronoi microarchitecture bone scaffold using Taguchi-grey relational analysis

3D printing bone scaffolds is a cutting-edge approach in bone tissue engineering, potentially resolving critical-sized bone defect challenges. While current research primarily focuses on tensile parameters in printing, compressive parameters are often overlooked despite their crucial role in scaffold performance. This study aimed to optimize the mechanical properties of bone scaffolds featuring Voronoi microarchitecture through tailored printing parameters. Utilizing the Taguchi method and Grey Relational Analysis (GRA), significant variations in mechanical parameters such as elastic modulus and compressive strength were identified among specimen groups. Key printing factors including layer height, line width, printing temperature, and printing speed proved pivotal in influencing the compressive strength and elastic modulus of polylactic acid (PLA) used in 3D printing. This research demonstrates the novelty of combining the Taguchi-GRA approach with the Voronoi microarchitecture to achieve superior mechanical properties. Specifically, optimal settings layer height of 0.0625 mm, line width of 0.25 mm, printing temperature of 215 °C, and printing speed of 55 mm/s, yielded scaffolds with enhanced compressive strength and elastic modulus, meeting biomechanical requirements for bone regeneration. Further investigation is warranted to establish comprehensive guidelines for achieving consistent mechanical excellence in 3D-printed PLA components, thereby advancing the efficacy and reliability of bone scaffold applications. The findings of this study provide a foundation for standardizing 3D printing protocols for bone scaffolds, bridging the gap between experimental designs and clinical applications. By addressing critical bottlenecks and introducing innovative solutions, this research contributes to advancing the field of bone tissue engineering and improving outcomes in regenerative medicine. patient outcomes in bone tissue engineering.

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来源期刊

Bioprinting Computer Science-Computer Science Applications

CiteScore

11.50

自引率

0.00%

发文量

审稿时长

68 days

期刊介绍： Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.