Pincer Ligand Facilitated Metal‐Catalyzed Multicomponent Reactions

Multicomponent reactions hold a significant position in the field of organic synthetic chemistry as they can rapidly construct structurally diverse molecules with high atom economy. Pincer ligands possess unique structural and electronic properties, exhibiting remarkable catalytic activity and selectivity in multicomponent reactions. This review systematically elaborates on the research progress of multicomponent reactions involving pincer ligands, thoroughly discussing their mechanism of action in different reaction systems, including crucial aspects such as substrate activation modes, the formation and transformation of reaction intermediates. Meanwhile, an in‐depth analysis of the relationship between the structures of various pincer ligands and their reaction performance is carried out, and multiple representative reaction examples are presented, such as multicomponent transformation processes of carbon‐carbon bond and carbon‐nitrogen bond formation reactions catalyzed by metal‐pincer complexes or metal‐pincer nanoclusters. Furthermore, the future development of multicomponent reactions involving pincer ligands are prospected. It is anticipated that they will play a more crucial role in the development of novel organic synthetic methodologies, drug synthesis, and materials science, providing valuable references and inspiration for researchers in related fields.