心肌酮体氧化有助于恩格列净诱导的小鼠心力衰竭心脏收缩力的改善

IF 16.9 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

European Journal of Heart Failure Pub Date : 2025-03-11 DOI:10.1002/ejhf.3633

Suzanne Nathalie Voorrips, Constantin Laurent Palm, Huitzilihuitl Saucedo-Orozco, Belend Mahmoud, Elisabeth Marloes Schouten, Anna M. Feringa, Pablo I. Sanchez-Aguilera, Kirsten T. Nijholt, Salva R. Yurista, Peter van der Meer, Herman H.W. Silljé, B. Daan Westenbrink

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引用次数: 0

摘要

钠-葡萄糖共转运蛋白2抑制剂（SGLT2i）可改善心力衰竭患者的心脏功能和临床结果，但这些有益作用的机制尚不完全清楚。我们试图确定sgltti诱导的心功能改善是否依赖于酮体心脏氧化的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Myocardial ketone body oxidation contributes to empagliflozin-induced improvements in cardiac contractility in murine heart failure

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Myocardial ketone body oxidation contributes to empagliflozin-induced improvements in cardiac contractility in murine heart failure

Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve cardiac performance and clinical outcomes in patients with heart failure, yet mechanisms underlying these beneficial effects remain incompletely understood. We sought to determine whether SGLT2i-induced improvements in cardiac function are dependent on increased cardiac oxidation of ketone bodies.

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来源期刊

European Journal of Heart Failure 医学-心血管系统

CiteScore

27.30

自引率

11.50%

发文量

365

审稿时长

1 months

期刊介绍： European Journal of Heart Failure is an international journal dedicated to advancing knowledge in the field of heart failure management. The journal publishes reviews and editorials aimed at improving understanding, prevention, investigation, and treatment of heart failure. It covers various disciplines such as molecular and cellular biology, pathology, physiology, electrophysiology, pharmacology, clinical sciences, social sciences, and population sciences. The journal welcomes submissions of manuscripts on basic, clinical, and population sciences, as well as original contributions on nursing, care of the elderly, primary care, health economics, and other related specialist fields. It is published monthly and has a readership that includes cardiologists, emergency room physicians, intensivists, internists, general physicians, cardiac nurses, diabetologists, epidemiologists, basic scientists focusing on cardiovascular research, and those working in rehabilitation. The journal is abstracted and indexed in various databases such as Academic Search, Embase, MEDLINE/PubMed, and Science Citation Index.