用于在近红外-II 窗口早期检测关节炎的软骨靶向荧光团

IF 19.6 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Chem Pub Date : 2025-08-14 DOI:10.1016/j.chempr.2025.102481

Homan Kang , Seung Hun Park , Guliz Ersoy Ozmen , Won Hur , Jason Dinh , Haoran Wang , Vy Nguyen , Sung Ahn , Atsushi Yamashita , Wesley R. Stiles , Satoshi Kashiwagi , Kai Bao , Maged Henary , Hak Soo Choi

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引用次数: 0

摘要

早期诊断对于有效治疗类风湿性关节炎至关重要，因为持续的炎症会导致不可逆转的关节损伤。然而，目前的诊断方法缺乏组织特异性指南来监测退行性关节疾病的进展过程。在这里，我们证明了软骨靶向荧光团（carf）表现出显著的软骨特异性亲和力，并在近红外II （NIR-II）窗口中提供先进的成像能力，其特征是最小的组织散射和可忽略的自身荧光。CARFs在体外（达100 μM）和体内（静脉注射3 μmol/kg）均表现出轻微或无毒性，具有临床应用潜力。此外，NIR-II窗口中的carf能够精确地显示软骨衬里，作为临床前小鼠模型中早期发现关节炎的可靠诊断指标。carf是一种近红外荧光靶向造影剂，用于关节组织的预后成像，在组织工程、关节手术和炎症性疾病的药物开发方面具有革命性的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cartilage-targeting fluorophores for early detection of arthritis in the NIR-II window

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Cartilage-targeting fluorophores for early detection of arthritis in the NIR-II window

Early diagnosis is crucial for the effective treatment of rheumatoid arthritis because continuing inflammation can lead to irreversible joint damage. However, current diagnostic methods lack tissue-specific guidelines to monitor the progressive course of degenerative joint diseases. Here, we demonstrate that cartilage-targeting fluorophores (CARFs) exhibit a remarkable cartilage-specific affinity and offer advanced imaging capabilities in the near-infrared II (NIR-II) window, characterized by minimal tissue scattering and negligible autofluorescence. CARFs show little to no toxicity, both in vitro (up to 100 μM) and in vivo (3 μmol/kg via intravenous injection), suggesting clinical potential. Furthermore, CARFs in the NIR-II window enable the precise visualization of cartilage lining, serving as a reliable diagnostic indicator for the early detection of arthritis in preclinical mouse models. CARFs are NIR fluorescence-emitting targeted contrast agents for prognostic imaging of joint tissue, with the potential to revolutionize applications in tissue engineering, joint surgery, and drug development for inflammatory diseases.

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来源期刊

Chem Environmental Science-Environmental Chemistry

CiteScore

32.40

自引率

1.30%

发文量

281

期刊介绍： Chem, affiliated with Cell as its sister journal, serves as a platform for groundbreaking research and illustrates how fundamental inquiries in chemistry and its related fields can contribute to addressing future global challenges. It was established in 2016, and is currently edited by Robert Eagling.