肾上腺皮质癌：临床医生的实用指南

IF 44 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

The Lancet Diabetes & Endocrinology Pub Date : 2025-03-11 DOI:10.1016/s2213-8587(24)00378-4

Martin Fassnacht, Soraya Puglisi, Otilia Kimpel, Massimo Terzolo

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引用次数: 0

摘要

肾上腺皮质癌是一种罕见的内分泌恶性肿瘤。由于多种原因，肾上腺皮质癌患者的管理具有挑战性，包括其异质性但经常具有侵袭性的生物学行为；与肿瘤相关的激素过量（如库欣综合征或男性化）；关于诊断、调查和治疗的证据总体缺乏；仅批准一种药物（米托坦）；以及缺乏经验丰富的中心。在这篇综述中，我们提出了25个关于成人肾上腺皮质癌患者临床管理中最重要的方面的问题，这些问题是我们在过去25年中经常问自己的。我们根据已发表的证据以及60多年的集体临床经验和来自我们在德国和意大利两个中心管理的1700多名患者的见解，提供我们个人的答案和观点。

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Adrenocortical carcinoma: a practical guide for clinicians

Adrenocortical carcinoma is a rare endocrine malignancy. The management of patients with adrenocortical carcinoma is challenging for several reasons, including its heterogeneous but frequently aggressive biological behaviour; tumour-related hormonal excess (eg, Cushing's syndrome or virilisation); the overall paucity of evidence regarding diagnostic investigation and treatment; the approval of only one drug (mitotane); and the scarcity of centres with sufficient experience. In this Review, we present 25 questions on the most important aspects of the clinical management of adult patients with adrenocortical carcinoma that we have frequently asked ourselves over the past 25 years. We offer our personal answers and perspectives, drawing upon published evidence as well as more than 60 years of collective clinical experience and insights from our management of more than 1700 patients across two centres in Germany and Italy.

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来源期刊

The Lancet Diabetes & Endocrinology ENDOCRINOLOGY & METABOLISM-

CiteScore

61.50

自引率

1.60%

发文量

371

期刊介绍： The Lancet Diabetes & Endocrinology, an independent journal with a global perspective and strong clinical focus, features original clinical research, expert reviews, news, and opinion pieces in each monthly issue. Covering topics like diabetes, obesity, nutrition, and more, the journal provides insights into clinical advances and practice-changing research worldwide. It welcomes original research advocating change or shedding light on clinical practice, as well as informative reviews on related topics, especially those with global health importance and relevance to low-income and middle-income countries. The journal publishes various content types, including Articles, Reviews, Comments, Correspondence, Health Policy, and Personal Views, along with Series and Commissions aiming to drive positive change in clinical practice and health policy in diabetes and endocrinology.