潜在的中枢神经系统活性剂。4(3H)-喹唑啉酮的研究。

Il Farmaco; edizione scientifica Pub Date : 1988-09-01
R Lakhan, R L Singh
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引用次数: 0

摘要

以2-硫-3-芳基-7-氯-4(3H)-喹唑啉酮为主要中间体,制备了新的2-氨基甲硫基-甲基硫和2-(- -二甲基氨基-烷基)硫-3-芳基-7-氯-4(3H)-喹唑啉酮。其中五种合成化合物对小鼠的中枢神经系统活性进行了筛选,发现它们要么是中枢神经系统抑制剂,要么是兴奋剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential CNS active agents. II--Studies of 4(3H)-quinazolinones.

Some new 2-carbamoylmethylthio- and 2-(omega-dimethylamino-alkyl)thio-3-aryl-7-chloro-4(3H)-quinazolinones have been prepared from 2-thio-3-aryl-7-chloro-4(3H)-quinazolinones as the key intermediate. Five of the synthetic compounds were screened for their CNS activities on mice and found to be either CNS depressants or stimulants.

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