卡铂诱导肺癌患者恶心和呕吐的年龄分层风险。

IF 2.5 3区医学 Q3 ONCOLOGY

Oncology Pub Date : 2025-03-10 DOI:10.1159/000544875

Koki Hashimoto, Takashi Yokokawa, Yuma Nonomiya, Naoki Shibata, Azusa Soejima, Kazuo Kobayashi, Yutaro Mae, Akiko Hasegawa, Takeshi Aoyama, Yoshikazu Tateai, Shuhei Ban, Kotono Nigata, Ryusei Abe, Kazuyoshi Kawakami, Hisanori Shimizu, Ryo Ariyasu, Noriko Yanagitani, Kaname Hasegawa, Takashi Kawaguchi, Masakazu Yamaguchi, Kenichi Suzuki

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引用次数: 0

摘要

导读：年龄被认为是化疗引起的恶心和呕吐的危险因素。然而，很少有报道描述卡铂（CBDCA）引起恶心和呕吐的危险因素。本研究调查了cbdca引起的恶心和呕吐的发生率是否随年龄而变化，以70岁为截止年龄。方法：将2020年11月至2023年10月期间在日本癌症研究基金会癌症研究所医院接受CBDCA治疗的肺癌患者纳入本回顾性研究。年龄限制设定为70岁，完全缓解(CR；观察期间无呕吐/干呕及无抢救用药)率为终点。结果：共纳入198例患者，其中年龄≥70岁114例（57.6%），CR率为36.9%

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Age-Stratified Risk of Carboplatin-Induced Nausea and Vomiting in Lung Cancer Patients.

Introduction: Age has been reported as a risk factor for chemotherapy-induced nausea and vomiting. However, few reports have described risk factors for nausea and vomiting with carboplatin (CBDCA). This study investigated whether the incidence of CBDCA-induced nausea and vomiting differs with age, using 70 years as the cutoff.

Methods: Patients who underwent CBDCA for lung cancer at the Cancer Institute Hospital of Japanese Foundation for Cancer Research between November 2020 and October 2023 were included in this retrospective study. The age cutoff was set at 70 years, with the complete response (CR; no vomiting/retching and no rescue medication) rate during the observation period as the endpoint.

Results: Of the 198 patients included in the analysis, 114 (57.6%) were ≥70 years old. The CR rate was 36.9% for patients <70 years old and 61.4% for patients ≥70 years old (p = 0.001). In univariate analyses, age <70 years, female sex, no drinking history, no smoking history, and higher CBDCA dose were associated with non-CR. In multivariate analysis, age <70 years, no drinking history, and higher CBDCA dose were associated with non-CR.

Conclusion: Age <70 years, no drinking history, and higher CBDCA dose were identified as risk factors for CBDCA-induced nausea and vomiting.

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来源期刊

Oncology 医学-肿瘤学

CiteScore

6.00

自引率

2.90%

发文量

审稿时长

6-12 weeks

期刊介绍： Although laboratory and clinical cancer research need to be closely linked, observations at the basic level often remain removed from medical applications. This journal works to accelerate the translation of experimental results into the clinic, and back again into the laboratory for further investigation. The fundamental purpose of this effort is to advance clinically-relevant knowledge of cancer, and improve the outcome of prevention, diagnosis and treatment of malignant disease. The journal publishes significant clinical studies from cancer programs around the world, along with important translational laboratory findings, mini-reviews (invited and submitted) and in-depth discussions of evolving and controversial topics in the oncology arena. A unique feature of the journal is a new section which focuses on rapid peer-review and subsequent publication of short reports of phase 1 and phase 2 clinical cancer trials, with a goal of insuring that high-quality clinical cancer research quickly enters the public domain, regardless of the trial’s ultimate conclusions regarding efficacy or toxicity.