吸入银、金、氧化铜和氧化锌纳米颗粒的生物动力学研究综述。

IF 3.6 3区 医学 Q3 NANOSCIENCE & NANOTECHNOLOGY
Niels Hadrup, Ulla Vogel, Nicklas R Jacobsen
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引用次数: 0

摘要

纳米材料毒性的理解是由指向潜在目标器官的生物动力学信息辅助的。银(Ag)、氧化铜(CuO)和氧化锌(ZnO)在文献中通常被称为可溶性物质。此外,数据表明金(Au)纳米颗粒可溶于哺乳动物体内。我们确定了这些物质的吸入研究,并提取了物理化学性质、器官分布和排泄的数据。银和金在肺中滞留时间较长(分别为2000小时和672小时);铜最初在肺中升高,然后在~ 500小时恢复到基线。短期暴露于氧化锌后,肺部锌含量增加,但长期暴露后没有增加。在血液中,银在吸入后开始增加,但在200小时内逐渐下降。暴露于4、7、11和13纳米颗粒(但不包括20、34和105纳米颗粒)后,血液中的金含量升高,并在暴露于4和11纳米颗粒后至少672小时内保持升高。银在肝脏和脾脏中增加,并且在暴露2000小时后仍然存在。暴露600多个小时后,包括脾脏和肾脏在内的几个器官中的黄金含量升高,表明某些器官中的黄金含量持续存在。大脑和嗅球中的银色和金色都有所增加。总的来说,我们发现四种纳米材料的生物分布没有太大的差异,但注意到在最后一次研究暴露后的时间点,银和金在几个器官中仍然增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biokinetics of inhaled silver, gold, copper oxide, and zinc oxide nanoparticles: a review.

The understanding of nanomaterial toxicity is aided by biokinetic information pointing to potential target organs. Silver (Ag), copper oxide (CuO), and zinc oxide (ZnO) are often referred to as soluble materials in the literature. In addition, data suggest gold (Au) nanoparticles to be soluble in the mammalian body. We identified inhalation studies on these materials and extracted data on physicochemical properties, organ distribution, and excretion. Silver and gold were retained in the lung for an extended period (>2,000 and >672 hours, respectively); copper initially increased in lung and then returned to baseline at ∼500 hours. Zinc increased in the lungs after short-term exposure to zinc oxide, but not after prolonged exposure. In blood, silver initially increased after inhalation but then gradually declined over ∼200 hours. Gold was elevated in the blood after exposure to 4, 7, 11, and 13 nm particles (but not particles of 20, 34, and 105 nm) and remained elevated for at least 672 hours after exposure to the 4 and 11 nm particles. Silver increased in the liver and spleen and was still present 2,000 hours post exposure. Gold was elevated in several organs, including the spleen and kidney, for more than 600 hours post exposure, indicating persistence in some organs. Both silver and gold were increased in the brain and olfactory bulb. Overall, we found no large differences in the biodistribution of the four nanomaterials but note that silver and gold were still increased in several organs at the last investigated post-exposure time points.

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来源期刊
Nanotoxicology
Nanotoxicology 医学-毒理学
CiteScore
10.10
自引率
4.00%
发文量
45
审稿时长
3.5 months
期刊介绍: Nanotoxicology invites contributions addressing research relating to the potential for human and environmental exposure, hazard and risk associated with the use and development of nano-structured materials. In this context, the term nano-structured materials has a broad definition, including ‘materials with at least one dimension in the nanometer size range’. These nanomaterials range from nanoparticles and nanomedicines, to nano-surfaces of larger materials and composite materials. The range of nanomaterials in use and under development is extremely diverse, so this journal includes a range of materials generated for purposeful delivery into the body (food, medicines, diagnostics and prosthetics), to consumer products (e.g. paints, cosmetics, electronics and clothing), and particles designed for environmental applications (e.g. remediation). It is the nano-size range if these materials which unifies them and defines the scope of Nanotoxicology . While the term ‘toxicology’ indicates risk, the journal Nanotoxicology also aims to encompass studies that enhance safety during the production, use and disposal of nanomaterials. Well-controlled studies demonstrating a lack of exposure, hazard or risk associated with nanomaterials, or studies aiming to improve biocompatibility are welcomed and encouraged, as such studies will lead to an advancement of nanotechnology. Furthermore, many nanoparticles are developed with the intention to improve human health (e.g. antimicrobial agents), and again, such articles are encouraged. In order to promote quality, Nanotoxicology will prioritise publications that have demonstrated characterisation of the nanomaterials investigated.
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