Alexander Halim Santoso, Edwin Destra, Yohanes Firmansyah, Susy Olivia Lontoh
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This study aims to investigate the associations between glucose profile, fasting insulin, renal function, and muscle strength among elderly residents of a single-centered nursing home in Indonesia, identifying potential biomarkers for sarcopenia.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted on 31 elderly residents of Santa Anna Nursing Home, with muscle strength measured using handgrip dynamometry and biochemical parameters evaluated through standardized laboratory methods.</p><p><strong>Results: </strong>Structural Equation Modeling-Partial Least Squares (SEM-PLS) analysis revealed strong negative correlations between glucose profile (β = -0.683, p < 0.01) and fasting insulin (β = -0.208, p < 0.05) with muscle strength, while renal function showed a moderate positive relationship (β = 0.295, p < 0.05).</p><p><strong>Conclusion: </strong>These findings highlight glucose profile, fasting insulin, and renal function as critical predictors of sarcopenia, offering potential pathways for early detection and targeted interventions. Future research should explore longitudinal assessments and molecular mechanisms to refine sarcopenia prevention strategies in aging populations.</p>","PeriodicalId":16357,"journal":{"name":"Journal of Multidisciplinary Healthcare","volume":"18 ","pages":"1393-1404"},"PeriodicalIF":2.7000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892493/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of Glucose Profile, Fasting Insulin, and Renal Function on Sarcopenia in Elderly at Single Centered Nursing Home: A Cross-Sectional Structural Equation Model Analysis.\",\"authors\":\"Alexander Halim Santoso, Edwin Destra, Yohanes Firmansyah, Susy Olivia Lontoh\",\"doi\":\"10.2147/JMDH.S486370\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Sarcopenia, characterized by a progressive decline in muscle mass and strength, poses significant public health challenges for the elderly, impacting physical performance and quality of life. 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引用次数: 0
摘要
背景：肌肉减少症以肌肉质量和力量的逐渐下降为特征，对老年人构成了重大的公共卫生挑战，影响了身体表现和生活质量。本研究旨在调查印度尼西亚一家单中心养老院的老年居民的血糖谱、空腹胰岛素、肾功能和肌肉力量之间的关系，确定肌肉减少症的潜在生物标志物。方法：对Santa Anna养老院31名老年人进行横断面分析，采用握力测量法测量肌力，采用标准化实验室方法评估生化指标。结果：结构方程模型-偏最小二乘（SEM-PLS）分析显示，葡萄糖谱（β = -0.683, p < 0.01）和空腹胰岛素谱（β = -0.208, p < 0.05）与肌力呈显著负相关，而肾功能呈中度正相关（β = 0.295, p < 0.05）。结论：这些发现强调了葡萄糖谱、空腹胰岛素和肾功能是肌少症的关键预测因素，为早期发现和有针对性的干预提供了潜在的途径。未来的研究应探索纵向评估和分子机制，以完善老年人群肌肉减少症的预防策略。
Impact of Glucose Profile, Fasting Insulin, and Renal Function on Sarcopenia in Elderly at Single Centered Nursing Home: A Cross-Sectional Structural Equation Model Analysis.
Background: Sarcopenia, characterized by a progressive decline in muscle mass and strength, poses significant public health challenges for the elderly, impacting physical performance and quality of life. This study aims to investigate the associations between glucose profile, fasting insulin, renal function, and muscle strength among elderly residents of a single-centered nursing home in Indonesia, identifying potential biomarkers for sarcopenia.
Methods: A cross-sectional analysis was conducted on 31 elderly residents of Santa Anna Nursing Home, with muscle strength measured using handgrip dynamometry and biochemical parameters evaluated through standardized laboratory methods.
Results: Structural Equation Modeling-Partial Least Squares (SEM-PLS) analysis revealed strong negative correlations between glucose profile (β = -0.683, p < 0.01) and fasting insulin (β = -0.208, p < 0.05) with muscle strength, while renal function showed a moderate positive relationship (β = 0.295, p < 0.05).
Conclusion: These findings highlight glucose profile, fasting insulin, and renal function as critical predictors of sarcopenia, offering potential pathways for early detection and targeted interventions. Future research should explore longitudinal assessments and molecular mechanisms to refine sarcopenia prevention strategies in aging populations.
期刊介绍：
The Journal of Multidisciplinary Healthcare (JMDH) aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. This includes studies and reviews conducted by multidisciplinary teams as well as research which evaluates or reports the results or conduct of such teams or healthcare processes in general. The journal covers a very wide range of areas and we welcome submissions from practitioners at all levels and from all over the world. Good healthcare is not bounded by person, place or time and the journal aims to reflect this. The JMDH is published as an open-access journal to allow this wide range of practical, patient relevant research to be immediately available to practitioners who can access and use it immediately upon publication.
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