辅酶Q10对谷氨酸钠诱导肥胖的认知功能障碍、抗氧化防御、胆碱能活性和海马神经元损伤的影响。

IF 1.8 4区 医学 Q3 PHARMACOLOGY & PHARMACY
Iranian Journal of Pharmaceutical Research Pub Date : 2025-01-05 eCollection Date: 2024-01-01 DOI:10.5812/ijpr-157068
Zahra Erfanmanesh, Mohammad Amin Edalatmanesh, Mokhtar Mokhtari
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引用次数: 0

摘要

背景:肥胖是一个日益严重的全球健康问题,与包括认知障碍在内的许多疾病有关。目的:研究辅酶Q10 (Co-Q10)对谷氨酸钠(MSG)致肥胖大鼠认知能力、抗氧化防御、胆碱能活性和海马神经元损伤的影响。方法:48只新生雄性Wistar大鼠随机分为对照组、味精组、味精+ Q10-10组和味精+ Q10-20组。谷氨酸钠(4 g/kg BW)从产后2天(PND)至产后10天(PND)皮下注入宫颈。辅酶Q10 (10 mg/kg BW和20 mg/kg BW)在PND 30至PND 42期间腹腔注射。在治疗期结束时,进行工作记忆和回避学习测试。收集人体测量数据,随后评估海马过氧化氢酶(CAT)、超氧化物歧化酶(SOD)、乙酰胆碱酯酶(AChE)、谷胱甘肽过氧化物酶(GPx)和丙二醛(MDA)水平。还评估了海马CA₁和CA₃区凋亡/暗神经元(DN)的密度。结果:谷氨酸钠处理小鼠体质量指数(BMI)和Lee指数升高,工作记忆和回避学习功能受损,CAT、SOD和GPx活性降低。此外,味精暴露导致MDA水平升高,AChE活性增加,CA₁和CA₃海马区域DN密度增加。用辅酶q10治疗导致BMI下降,记忆力和学习能力增强,海马中CAT、SOD和GPx活性显著增加,CA₁和CA₃区域的MDA水平、AChE活性和DN密度降低。结论:辅酶Q10减轻海马神经元损伤,改善认知功能,主要是通过其抗氧化和乙酰胆碱酯酶抑制特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Impact of Coenzyme Q10 on Cognitive Dysfunction, Antioxidant Defense, Cholinergic Activity, and Hippocampal Neuronal Damage in Monosodium Glutamate-Induced Obesity.

Background: Obesity, a rising global health issue, is linked to numerous disorders, including cognitive impairment.

Objectives: This study investigates the effects of coenzyme Q10 (Co-Q10) on cognitive performance, antioxidant defense, cholinergic activity, and hippocampal neuron damage in rats rendered obese by monosodium glutamate (MSG) exposure.

Methods: Forty-eight neonatal male Wistar rats were randomly assigned to one of four groups: Control, MSG, MSG + Q10-10, and MSG + Q10-20. Monosodium glutamate (4 g/kg BW) was administered subcutaneously into the cervical region from postnatal day (PND) 2 to PND 10. Coenzyme Q10 (10 mg/kg BW and 20 mg/kg BW) was administered intraperitoneally from PND 30 to PND 42. At the end of the treatment period, working memory and avoidance learning tests were conducted. Anthropometric data were collected, followed by evaluations of hippocampal catalase (CAT), superoxide dismutase (SOD), acetylcholinesterase (AChE), glutathione peroxidase (GPx), and malondialdehyde (MDA) levels. The density of apoptotic/dark neurons (DN) in the CA₁ and CA₃ regions of the hippocampus was also assessed.

Results: Monosodium glutamate treatment increased Body Mass Index (BMI) and Lee Index, impaired working memory and avoidance learning, and reduced CAT, SOD, and GPx activities. Additionally, MSG exposure led to elevated MDA levels, increased AChE activity, and higher DN density in the CA₁ and CA₃ hippocampal regions. Treatment with Co-Q10 resulted in a decrease in BMI, enhanced memory and learning, noteworthy increases in CAT, SOD, and GPx activities in the hippocampus, and reductions in MDA levels, AChE activity, and DN density in the CA₁ and CA₃ regions.

Conclusions: Coenzyme Q10 mitigates hippocampal neuronal damage and improves cognitive function in MSG-induced obesity, primarily through its antioxidant and AChE inhibitory properties.

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来源期刊
CiteScore
3.40
自引率
6.20%
发文量
52
审稿时长
2 months
期刊介绍: The Iranian Journal of Pharmaceutical Research (IJPR) is a peer-reviewed multi-disciplinary pharmaceutical publication, scheduled to appear quarterly and serve as a means for scientific information exchange in the international pharmaceutical forum. Specific scientific topics of interest to the journal include, but are not limited to: pharmaceutics, industrial pharmacy, pharmacognosy, toxicology, medicinal chemistry, novel analytical methods for drug characterization, computational and modeling approaches to drug design, bio-medical experience, clinical investigation, rational drug prescribing, pharmacoeconomics, biotechnology, nanotechnology, biopharmaceutics and physical pharmacy.
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