Amalia Namath, Jonathan M Konel, Jing Wu, Adina Schwartz, Wayne Caswell, Jeanne E O'Brien, Stephanie Beall
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引用次数: 0
摘要
目的评估辅助孵化对使用玻璃化供体卵母细胞进行新鲜胚胎移植的植入率和妊娠率的影响：设计：回顾性队列研究：2015年至2020年期间，参与美国捐卵库数据库的29个试管婴儿中心：暴露：辅助孵化：辅助孵化.主要结果测量指标：植入率、临床妊娠率、自然流产率和持续妊娠率：在 2,617 个胚胎中，1,668 个（64%）进行了辅助孵化。辅助孵化组与非辅助孵化组相比，每次移植的生化妊娠率和临床妊娠率明显较低（72% vs 76%，aRR 0.94，95% CI 0.9-0.99，p结论：辅助孵化可能与胚胎植入有关：辅助孵化可能会降低供卵周期的临床妊娠率和持续妊娠率。
Assisted hatching decreases pregnancy outcomes in vitrified donor oocytes.
Objective: To evaluate the impact of assisted hatching on implantation and pregnancy rates among fresh embryo transfers using vitrified donor oocytes.
Design: Retrospective cohort study.
Subjects: Oocyte donor recipients.
Exposure: Assisted hatching.
Main outcome measures: Rates of implantation, clinical pregnancy, spontaneous abortion, and ongoing pregnancy.
Results: Among the 2,617 embryos, 1,668 (64%) underwent assisted hatching. The biochemical pregnancy rate per transfer and clinical pregnancy rate per transfer were significantly lower for the assisted hatching group vs. non-assisted hatching group (72% vs. 76%; adjusted risk ratio (aRR), 0.94; 95% confidence interval [CI], 0.9-0.99 and 61% vs. 66%; aRR, 0.92; 95% CI, 0.86-0.97). The assisted hatching group also had a lower ongoing/sustained pregnancy rate (57% vs. 62%; aRR, 0.91; 95% CI, 0.78-0.91) compared with the non-assisted hatching group. Spontaneous abortion may be higher for the assisted hatching group compared with the non-assisted hatching group, although not statistically significant (13% vs. 11%).
Conclusion: Assisted hatching may be associated with decreased clinical and ongoing pregnancy rates in donor oocyte cycles.
期刊介绍：
Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.
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