68Ga-exendin-4在WHO 3级胰岛素瘤和广泛肝内转移患者中的强烈摄取

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-11 DOI:10.1097/RLU.0000000000005834

Hongzhe Zhang, Qingqing Pan, Silu Liu, Jie Feng, Yaping Luo

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引用次数: 0

摘要

一位24岁的女性，患有高胰岛素性低血糖，在CT和MRI中发现胰腺肿块和多发肝内病变。68Ga-exendin-4 PET/CT示胰腺肿块及所有肝内病变呈强放射性，提示恶性胰岛素瘤伴多发肝内转移。随后的细针活检证实了WHO 3级胰岛素瘤的诊断。高级别恶性胰岛素瘤中胰高血糖素样肽-1受体（GLP-1R）广泛表达的病例突出了GLP-1R靶向PRRT在未来临床研究中的潜力。

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Intense Uptake of 68 Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.

A 24-year-old woman with hyperinsulinemic hypoglycemia was found with a pancreatic mass and multiple intrahepatic lesions in CT and MRI. 68 Ga-exendin-4 PET/CT showed intense radioactivity in the pancreatic mass and all the intrahepatic lesions, suggesting a malignant insulinoma with multiple intrahepatic metastases. Subsequent fine needle biopsy confirmed the diagnosis of WHO grade 3 insulinoma. This case with extensive glucagon-like peptide-1 receptor (GLP-1R) expression in a high-grade malignant insulinoma highlighted the potential of GLP-1R-targeted PRRT in future clinical studies.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.