{"title":"First Clinical Application of 99mTc-FAPI-46 as an Available Radiotracer to Evaluate the Cardiac Remodeling Process: A Case Report.","authors":"Nasrin Raeisi, Amin Saber Tanha, Kamran Aryana, Sadegh Nazif, Somaye Barashki","doi":"10.1097/RLU.0000000000005821","DOIUrl":null,"url":null,"abstract":"<p><p>We present a 67-year-old woman with a history of coronary artery bypass graft surgery, who experienced recent chest pain. Myocardial perfusion imaging and 99mTc-FAPI-46 SPECT were performed to assess myocardial infarction. The dynamic FAPI imaging indicated sustained myocardial activity. Myocardial perfusion imaging identified extensive myocardial infarction and ischemia, while FAPI uptake slightly overestimated the infarct extension. Coronary angiography correlated well with these findings. FAPI PET/CT is increasingly being used to monitor cardiac remodeling. This pioneering experience with 99mTc-FAPI-46 showcases comparable results to PET/CT, providing valuable insights into cardiac remodeling processes and highlighting the potential of 99mTc-FAPI-46 in cardiac imaging.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/RLU.0000000000005821","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
First Clinical Application of 99mTc-FAPI-46 as an Available Radiotracer to Evaluate the Cardiac Remodeling Process: A Case Report.
We present a 67-year-old woman with a history of coronary artery bypass graft surgery, who experienced recent chest pain. Myocardial perfusion imaging and 99mTc-FAPI-46 SPECT were performed to assess myocardial infarction. The dynamic FAPI imaging indicated sustained myocardial activity. Myocardial perfusion imaging identified extensive myocardial infarction and ischemia, while FAPI uptake slightly overestimated the infarct extension. Coronary angiography correlated well with these findings. FAPI PET/CT is increasingly being used to monitor cardiac remodeling. This pioneering experience with 99mTc-FAPI-46 showcases comparable results to PET/CT, providing valuable insights into cardiac remodeling processes and highlighting the potential of 99mTc-FAPI-46 in cardiac imaging.
期刊介绍：
Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty.
Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.
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