Juliet Briggs, Elizabeth Ralston, Thomas J Wilkinson, Christy Walklin, Emmanuel Mangahis, Hannah M L Young, Ellen M Castle, Roseanne E Billany, Elham Asgari, Sunil Bhandari, Kate Bramham, James O Burton, Jackie Campbell, Joseph Chilcot, Vashist Deelchand, Alexander Hamilton, Mark Jesky, Philip A Kalra, Kieran McCafferty, Andrew C Nixon, Zoe L Saynor, Maarten W Taal, James Tollitt, David C Wheeler, Jamie Macdonald, Sharlene A Greenwood
{"title":"通过 Kidney BEAM 平台对多囊肾患者进行数字体育锻炼干预：随机对照试验。","authors":"Juliet Briggs, Elizabeth Ralston, Thomas J Wilkinson, Christy Walklin, Emmanuel Mangahis, Hannah M L Young, Ellen M Castle, Roseanne E Billany, Elham Asgari, Sunil Bhandari, Kate Bramham, James O Burton, Jackie Campbell, Joseph Chilcot, Vashist Deelchand, Alexander Hamilton, Mark Jesky, Philip A Kalra, Kieran McCafferty, Andrew C Nixon, Zoe L Saynor, Maarten W Taal, James Tollitt, David C Wheeler, Jamie Macdonald, Sharlene A Greenwood","doi":"10.1093/ckj/sfaf041","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD.</p><p><strong>Methods: </strong>This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews.</p><p><strong>Results: </strong>All 60 individuals (mean 53 years, 37% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95% confidence interval 1.0-7.4) arbitrary units, <i>P =</i> .012]. Significant between-group differences in KDQoL subscales-burden of kidney disease (<i>P</i> = .034), emotional wellbeing (<i>P</i> = .001) and energy/fatigue (<i>P</i> = .001)-were also achieved. There was no significant between-group difference in KDQoL PCS scores (<i>P</i> = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (<i>P</i> = .010) and body mass (<i>P</i> = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management.</p><p><strong>Conclusion: </strong>A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour.</p>","PeriodicalId":10435,"journal":{"name":"Clinical Kidney Journal","volume":"18 3","pages":"sfaf041"},"PeriodicalIF":3.9000,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892433/pdf/","citationCount":"0","resultStr":"{\"title\":\"Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial.\",\"authors\":\"Juliet Briggs, Elizabeth Ralston, Thomas J Wilkinson, Christy Walklin, Emmanuel Mangahis, Hannah M L Young, Ellen M Castle, Roseanne E Billany, Elham Asgari, Sunil Bhandari, Kate Bramham, James O Burton, Jackie Campbell, Joseph Chilcot, Vashist Deelchand, Alexander Hamilton, Mark Jesky, Philip A Kalra, Kieran McCafferty, Andrew C Nixon, Zoe L Saynor, Maarten W Taal, James Tollitt, David C Wheeler, Jamie Macdonald, Sharlene A Greenwood\",\"doi\":\"10.1093/ckj/sfaf041\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD.</p><p><strong>Methods: </strong>This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews.</p><p><strong>Results: </strong>All 60 individuals (mean 53 years, 37% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95% confidence interval 1.0-7.4) arbitrary units, <i>P =</i> .012]. Significant between-group differences in KDQoL subscales-burden of kidney disease (<i>P</i> = .034), emotional wellbeing (<i>P</i> = .001) and energy/fatigue (<i>P</i> = .001)-were also achieved. There was no significant between-group difference in KDQoL PCS scores (<i>P</i> = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (<i>P</i> = .010) and body mass (<i>P</i> = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management.</p><p><strong>Conclusion: </strong>A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour.</p>\",\"PeriodicalId\":10435,\"journal\":{\"name\":\"Clinical Kidney Journal\",\"volume\":\"18 3\",\"pages\":\"sfaf041\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2025-02-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892433/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Kidney Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/ckj/sfaf041\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/3/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Kidney Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/ckj/sfaf041","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Digital physical activity intervention via the Kidney BEAM platform in patients with polycystic kidney disease: a randomized controlled trial.
Background: In people living with polycystic kidney disease (PKD), physical inactivity may contribute to poor health-related quality of life (HRQoL). To date, no research has elucidated the impact of a PKD-specific physical activity programme on HRQoL and physical health. This substudy of the Kidney BEAM Trial evaluated the impact of a PKD-specific 12-week educational and physical activity digital health intervention for people living with PKD.
Methods: This study was a mixed-methods, single-blind, randomized waitlist-controlled trial. Sixty adults with a diagnosis of PKD were randomized 1:1 to the intervention or a waitlist control group. Primary outcome was difference in the Kidney Disease QoL Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between baseline and 12 weeks. Six participants completed individualized semi-structured interviews.
Results: All 60 individuals (mean 53 years, 37% male) were included in the intention-to-treat analysis. At 12 weeks, there was a significant difference in mean adjusted change in KDQoL MCS score between the intervention group and waitlist control [4.2 (95% confidence interval 1.0-7.4) arbitrary units, P = .012]. Significant between-group differences in KDQoL subscales-burden of kidney disease (P = .034), emotional wellbeing (P = .001) and energy/fatigue (P = .001)-were also achieved. There was no significant between-group difference in KDQoL PCS scores (P = .505). Per-protocol analyses revealed significant between group differences in the PAM-13 patient activation score (P = .010) and body mass (P = .027). Mixed-methods analyses revealed key influences of the programme, including opportunities for peer support and to build on new skills and knowledge, as well as the empowerment and self-management.
Conclusion: A PKD-specific digital health educational and physical activity intervention is acceptable and has the potential to improve HRQoL. Further research is needed to better understand how specific education and lifestyle management may help to support self-management behaviour.
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About the Journal
Clinical Kidney Journal: Clinical and Translational Nephrology (ckj), an official journal of the ERA-EDTA (European Renal Association-European Dialysis and Transplant Association), is a fully open access, online only journal publishing bimonthly. The journal is an essential educational and training resource integrating clinical, translational and educational research into clinical practice. ckj aims to contribute to a translational research culture among nephrologists and kidney pathologists that helps close the gap between basic researchers and practicing clinicians and promote sorely needed innovation in the Nephrology field. All research articles in this journal have undergone peer review.
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