Xingqin Huang, Jiasi Zhang, Na Shen, Xia Wang, Linglin Jiang, Xiaofen Zeng, Keyu Liu
{"title":"b淋巴母细胞白血病/淋巴瘤中母细胞多裂核与TCF3::PBX1融合的关系","authors":"Xingqin Huang, Jiasi Zhang, Na Shen, Xia Wang, Linglin Jiang, Xiaofen Zeng, Keyu Liu","doi":"10.7754/Clin.Lab.2024.240904","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Several particular kinds of typical morphology characteristics of leukemic blasts associated with the specific subtypes of leukemia have been reported. However, B acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) has rarely been reported. The purpose of this study was to investigate the correlation of TCF3::PBX1 fusion with multiple clefts nuclei of blasts in patients with B-ALL/LBL.</p><p><strong>Methods: </strong>We retrospectively reviewed peripheral blood (PB) and bone marrow (BM) smears of 145 patients prepared at the time of initial diagnosis of B-ALL/LBL based on the results of testing for the TCF3::PBX1 fusion.</p><p><strong>Results: </strong>We investigated the association among this morphological phenotype and hematologic findings, disease markers, fusions of TCF3::PBX1, BCR::ABL1, and ETV6::RUNX1, KMT2A rearrangement, and no such fusions and rearrangements. Multiple clefts nuclei of blasts were found in 13 patients (8.97%) diagnosed with B-ALL/ LBL. Positive association between multiple clefts nuclei of blasts and TCF3::PBX1 fusion in patients with B-ALL/ LBL was observed after full adjustment for all the confounding variables (p < 0.05).</p><p><strong>Conclusions: </strong>The morphology of multiple clefts nuclei in blasts was strongly correlated with TCF3::PBX1 fusion in patients with B-ALL/LBL. Therefore, testing for TCF3::PBX1 fusions is recommended for patients with the morphology of multiple clefts nuclei in blasts.</p>","PeriodicalId":10384,"journal":{"name":"Clinical laboratory","volume":"71 3","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of Multiple Clefts Nuclei in Blasts with TCF3::PBX1 Fusion in B-Lymphoblastic Leukemia/Lymphoma.\",\"authors\":\"Xingqin Huang, Jiasi Zhang, Na Shen, Xia Wang, Linglin Jiang, Xiaofen Zeng, Keyu Liu\",\"doi\":\"10.7754/Clin.Lab.2024.240904\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Several particular kinds of typical morphology characteristics of leukemic blasts associated with the specific subtypes of leukemia have been reported. However, B acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) has rarely been reported. The purpose of this study was to investigate the correlation of TCF3::PBX1 fusion with multiple clefts nuclei of blasts in patients with B-ALL/LBL.</p><p><strong>Methods: </strong>We retrospectively reviewed peripheral blood (PB) and bone marrow (BM) smears of 145 patients prepared at the time of initial diagnosis of B-ALL/LBL based on the results of testing for the TCF3::PBX1 fusion.</p><p><strong>Results: </strong>We investigated the association among this morphological phenotype and hematologic findings, disease markers, fusions of TCF3::PBX1, BCR::ABL1, and ETV6::RUNX1, KMT2A rearrangement, and no such fusions and rearrangements. Multiple clefts nuclei of blasts were found in 13 patients (8.97%) diagnosed with B-ALL/ LBL. Positive association between multiple clefts nuclei of blasts and TCF3::PBX1 fusion in patients with B-ALL/ LBL was observed after full adjustment for all the confounding variables (p < 0.05).</p><p><strong>Conclusions: </strong>The morphology of multiple clefts nuclei in blasts was strongly correlated with TCF3::PBX1 fusion in patients with B-ALL/LBL. Therefore, testing for TCF3::PBX1 fusions is recommended for patients with the morphology of multiple clefts nuclei in blasts.</p>\",\"PeriodicalId\":10384,\"journal\":{\"name\":\"Clinical laboratory\",\"volume\":\"71 3\",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical laboratory\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.7754/Clin.Lab.2024.240904\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MEDICAL LABORATORY TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical laboratory","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.7754/Clin.Lab.2024.240904","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：几种与白血病特定亚型相关的白血病母细胞的典型形态学特征已被报道。然而，B急性淋巴细胞白血病/淋巴瘤（B- all /LBL）很少报道。本研究的目的是探讨TCF3::PBX1融合与B-ALL/LBL患者多发裂核的相关性。方法：根据TCF3::PBX1融合检测结果，回顾性分析145例B-ALL/LBL患者初诊时的外周血（PB）和骨髓（BM）涂片。结果：我们研究了这种形态表型与血液学结果、疾病标志物、TCF3::PBX1、BCR::ABL1和ETV6::RUNX1融合、KMT2A重排和无这种融合和重排之间的关系。诊断为B-ALL/ LBL的患者13例（8.97%）发现多发裂核。在完全校正所有混杂变量后，B-ALL/ LBL患者多发裂核与TCF3::PBX1融合呈正相关（p < 0.05）。结论：B-ALL/LBL患者原细胞多裂核形态与TCF3::PBX1融合密切相关。因此，对于具有多发裂核形态的患者，建议检测TCF3::PBX1融合。
Association of Multiple Clefts Nuclei in Blasts with TCF3::PBX1 Fusion in B-Lymphoblastic Leukemia/Lymphoma.
Background: Several particular kinds of typical morphology characteristics of leukemic blasts associated with the specific subtypes of leukemia have been reported. However, B acute lymphoblastic leukemia/lymphoma (B-ALL/LBL) has rarely been reported. The purpose of this study was to investigate the correlation of TCF3::PBX1 fusion with multiple clefts nuclei of blasts in patients with B-ALL/LBL.
Methods: We retrospectively reviewed peripheral blood (PB) and bone marrow (BM) smears of 145 patients prepared at the time of initial diagnosis of B-ALL/LBL based on the results of testing for the TCF3::PBX1 fusion.
Results: We investigated the association among this morphological phenotype and hematologic findings, disease markers, fusions of TCF3::PBX1, BCR::ABL1, and ETV6::RUNX1, KMT2A rearrangement, and no such fusions and rearrangements. Multiple clefts nuclei of blasts were found in 13 patients (8.97%) diagnosed with B-ALL/ LBL. Positive association between multiple clefts nuclei of blasts and TCF3::PBX1 fusion in patients with B-ALL/ LBL was observed after full adjustment for all the confounding variables (p < 0.05).
Conclusions: The morphology of multiple clefts nuclei in blasts was strongly correlated with TCF3::PBX1 fusion in patients with B-ALL/LBL. Therefore, testing for TCF3::PBX1 fusions is recommended for patients with the morphology of multiple clefts nuclei in blasts.
期刊介绍：
Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
