褪黑素通过TMEM110信号通路增加自噬水平促进炎症PDLSCs成骨

IF 8.3 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Xinyue Xu, Zhaojia Zhang, Wen Tian, Meng Cao, Zhen Wang, Fei Li, Tian Gao, Mengjuan Cheng, Yunlong Xia, Jinlong Shao, Chunxu Hai
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引用次数: 0

摘要

牙周韧带干细胞(Periodontal ligament stem cells, PDLSCs)的出现为牙周组织修复不良、再生受损的患者带来了新的希望。然而,复杂的炎症微环境持续抑制干细胞功能,阻碍干细胞治疗的有效性。褪黑素是一种自然产生的神经激素,参与调节多种生物功能。我们在体内和体外研究了褪黑素对牙周组织再生的影响。结果显示,褪黑素促进牙周炎的恢复,并增强炎症PDLSCs (Inf-PDLSCs)的成骨作用,其浓度不同。进一步的机制探索表明,自噬激活在褪黑激素治疗后的if - pdlscs成骨分化中发挥了重要作用。此外,褪黑素诱导的TEME110上调参与了nf- pdlscs自噬激活的启动和成骨的增强。总之,我们的研究结果提供了证据,褪黑素介导的if - pdlscs成骨对牙周组织再生很重要。此外,褪黑素作为治疗牙周炎的药物值得进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways

Melatonin Increased Autophagy Level to Facilitate Osteogenesis of Inflamed PDLSCs Through TMEM110 Signaling Pathways

Periodontal ligament stem cells (PDLSCs) bring new hope to patients with poor periodontium recovery and impaired regeneration. However, the complex inflammatory microenvironment continually inhibits stem cell function and hinders stem cell therapy effectiveness. Melatonin is a naturally occurring neurohormone that participates in the regulation of a large spectrum of biological functions. We investigated the effect of melatonin on periodontium regeneration both in vitro and in vivo. The results showed that melatonin promoted periodontitis recovery and enhanced the osteogenesis of inflamed PDLSCs (Inf-PDLSCs) depending on concentrations. Further mechanistic exploration indicated that autophagy activation played a significant role in enhancing the osteogenic differentiation of Inf-PDLSCs after melatonin treatment. Additionally, melatonin-induced upregulation of TEME110 participated in the initiation of autophagy activation and enhancement of osteogenesis in Inf-PDLSCs. Collectively, the results of our study provide evidence that melatonin-mediated osteogenesis of Inf-PDLSCs is important for periodontal tissue regeneration. Moreover, melatonin as a therapeutic drug for periodontitis treatment deserves further investigation.

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来源期刊
Journal of Pineal Research
Journal of Pineal Research 医学-内分泌学与代谢
CiteScore
17.70
自引率
4.90%
发文量
66
审稿时长
1 months
期刊介绍: The Journal of Pineal Research welcomes original scientific research on the pineal gland and melatonin in vertebrates, as well as the biological functions of melatonin in non-vertebrates, plants, and microorganisms. Criteria for publication include scientific importance, novelty, timeliness, and clarity of presentation. The journal considers experimental data that challenge current thinking and welcomes case reports contributing to understanding the pineal gland and melatonin research. Its aim is to serve researchers in all disciplines related to the pineal gland and melatonin.
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