Winicius Ruis de Souza, Bruna V. Quevedo, Pâmela Soto Garcia, Lucas Camargo Soares Carvalho da Silva, Daniel Komatsu, Eliana Aparecida de Rezende Duek
{"title":"透明质酸接枝壳聚糖的合成及其在生物材料中的应用前景","authors":"Winicius Ruis de Souza, Bruna V. Quevedo, Pâmela Soto Garcia, Lucas Camargo Soares Carvalho da Silva, Daniel Komatsu, Eliana Aparecida de Rezende Duek","doi":"10.1007/s00289-024-05595-1","DOIUrl":null,"url":null,"abstract":"<div><p>Chitosan (Chit) is a naturally derived polymer with significant potential for applications in medicine and pharmacology. Despite its biological activity, biocompatibility, cost-effectiveness, biodegradability, and low toxicity, Chit limited water solubility at pH < 6, restricts its use in biological fields, especially in medicine. To overcome this limitation, the study proposes the graphitization of Chit with hyaluronic acid (HA) (Chit-HA). The graphitization was confirmed by Fourier Transform Infrared Spectroscopy (FTIR) and Hydrogen Nuclear Magnetic Resonance Spectroscopy (<sup>1</sup>H NMR) analysis. In this work the grafting yield percentage was 75.2%<i>.</i> Thermogravimetric Analysis (TGA) showed an increasing stage of mass loss for Chit-HA, attributed to the decomposition of HA in the Chit chain. Differential Scanning Calorimetry (DSC) revealed a new exothermic peak at 256.9 °C for Chit-HA, indicating the thermal degradation of HA grafted onto the Chit chain. Solubility assay demonstrated an increase in water solubility for Chit-HA compared to Chit. In contrast to the Chit sample, the Zeta Potential measurements of Chit-HA exhibited negative charge throughout the analyzed pH range. Therefore, the results confirm the successful grafting of Chit with HA, resulting in a new material with potential application in the biomedical field.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":737,"journal":{"name":"Polymer Bulletin","volume":"82 6","pages":"1915 - 1933"},"PeriodicalIF":3.1000,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and physical–chemical characterization of chitosan grafted with hyaluronic acid as potential application in biomaterials\",\"authors\":\"Winicius Ruis de Souza, Bruna V. Quevedo, Pâmela Soto Garcia, Lucas Camargo Soares Carvalho da Silva, Daniel Komatsu, Eliana Aparecida de Rezende Duek\",\"doi\":\"10.1007/s00289-024-05595-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Chitosan (Chit) is a naturally derived polymer with significant potential for applications in medicine and pharmacology. Despite its biological activity, biocompatibility, cost-effectiveness, biodegradability, and low toxicity, Chit limited water solubility at pH < 6, restricts its use in biological fields, especially in medicine. To overcome this limitation, the study proposes the graphitization of Chit with hyaluronic acid (HA) (Chit-HA). The graphitization was confirmed by Fourier Transform Infrared Spectroscopy (FTIR) and Hydrogen Nuclear Magnetic Resonance Spectroscopy (<sup>1</sup>H NMR) analysis. In this work the grafting yield percentage was 75.2%<i>.</i> Thermogravimetric Analysis (TGA) showed an increasing stage of mass loss for Chit-HA, attributed to the decomposition of HA in the Chit chain. Differential Scanning Calorimetry (DSC) revealed a new exothermic peak at 256.9 °C for Chit-HA, indicating the thermal degradation of HA grafted onto the Chit chain. Solubility assay demonstrated an increase in water solubility for Chit-HA compared to Chit. In contrast to the Chit sample, the Zeta Potential measurements of Chit-HA exhibited negative charge throughout the analyzed pH range. Therefore, the results confirm the successful grafting of Chit with HA, resulting in a new material with potential application in the biomedical field.</p><h3>Graphical abstract</h3>\\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>\",\"PeriodicalId\":737,\"journal\":{\"name\":\"Polymer Bulletin\",\"volume\":\"82 6\",\"pages\":\"1915 - 1933\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-12-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Polymer Bulletin\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s00289-024-05595-1\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"POLYMER SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer Bulletin","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00289-024-05595-1","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
Synthesis and physical–chemical characterization of chitosan grafted with hyaluronic acid as potential application in biomaterials
Chitosan (Chit) is a naturally derived polymer with significant potential for applications in medicine and pharmacology. Despite its biological activity, biocompatibility, cost-effectiveness, biodegradability, and low toxicity, Chit limited water solubility at pH < 6, restricts its use in biological fields, especially in medicine. To overcome this limitation, the study proposes the graphitization of Chit with hyaluronic acid (HA) (Chit-HA). The graphitization was confirmed by Fourier Transform Infrared Spectroscopy (FTIR) and Hydrogen Nuclear Magnetic Resonance Spectroscopy (1H NMR) analysis. In this work the grafting yield percentage was 75.2%. Thermogravimetric Analysis (TGA) showed an increasing stage of mass loss for Chit-HA, attributed to the decomposition of HA in the Chit chain. Differential Scanning Calorimetry (DSC) revealed a new exothermic peak at 256.9 °C for Chit-HA, indicating the thermal degradation of HA grafted onto the Chit chain. Solubility assay demonstrated an increase in water solubility for Chit-HA compared to Chit. In contrast to the Chit sample, the Zeta Potential measurements of Chit-HA exhibited negative charge throughout the analyzed pH range. Therefore, the results confirm the successful grafting of Chit with HA, resulting in a new material with potential application in the biomedical field.
期刊介绍：
"Polymer Bulletin" is a comprehensive academic journal on polymer science founded in 1988. It was founded under the initiative of the late Mr. Wang Baoren, a famous Chinese chemist and educator. This journal is co-sponsored by the Chinese Chemical Society, the Institute of Chemistry, and the Chinese Academy of Sciences and is supervised by the China Association for Science and Technology. It is a core journal and is publicly distributed at home and abroad.
"Polymer Bulletin" is a monthly magazine with multiple columns, including a project application guide, outlook, review, research papers, highlight reviews, polymer education and teaching, information sharing, interviews, polymer science popularization, etc. The journal is included in the CSCD Chinese Science Citation Database. It serves as the source journal for Chinese scientific and technological paper statistics and the source journal of Peking University's "Overview of Chinese Core Journals."
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
