槲皮素碳点促进雪旺细胞的增殖和迁移，促进神经突的生长

IF 5.6 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-03-07 DOI:10.1016/j.colsurfb.2025.114609

Phanindra Babu Kasi , Henry Opoku , Liudmila N. Novikova , Mikael Wiberg , Paul J. Kingham , Jia Wang , Lev N. Novikov

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引用次数: 0

摘要

槲皮素是一种黄酮类化合物，以其抗氧化特性而闻名，最近作为治疗受损神经系统的潜在神经保护剂引起了人们的关注。周围神经损伤的修复取决于雪旺细胞的增殖和迁移，而雪旺细胞在支持轴突生长和髓鞘形成中起着至关重要的作用。本研究合成了槲皮素衍生碳点（QCDs），并研究了其对培养的雪旺细胞和NG108-15细胞系的影响。通过溶剂热合成得到了QCDs，并通过紫外可见吸收光谱、透射电镜、傅里叶变换红外光谱和x射线衍射分析对其进行了表征。在DPPH和ABTS自由基清除实验中，颗粒显示出显著的剂量依赖性自由基清除活性，支持雪旺细胞的体外增殖和迁移，神经营养和血管生成生长因子的表达，并刺激NG108-15细胞的神经突生长。因此，QCDs可以作为一种潜在的新治疗策略来促进受损周围神经系统的再生。

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Quercetin-derived carbon dots promote proliferation and migration of Schwann cells and enhance neurite outgrowth

Quercetin, a flavonoid known for its antioxidant properties, has recently garnered attention as a potential neuroprotective agent for treatment of the injured nervous system. The repair of peripheral nerve injuries hinges on the proliferation and migration of Schwann cells, which play a crucial role in supporting axonal growth and myelination. In this study we synthesized Quercetin-derived carbon dots (QCDs) and investigated their effects on cultured Schwann cells and the NG108-15 cell line. QCDs was obtained by solvothermal synthesis and characterized via UV–vis absorption spectroscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction analysis. The particles demonstrated significant dose-dependent free radical scavenging activity in DPPH and ABTS radical scavenging assays, supported in vitro proliferation and migration of Schwann cells, expression of neurotrophic and angiogenic growth factors, and stimulated neurite outgrowth from NG108-15 cells. Thus, QCDs could serve as a potential novel treatment strategy to promote regeneration in the injured peripheral nervous system.

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.