Recent advances in synergistic effect of lactoferrin

Lactoferrin (LF) is a multifunctional iron-binding glycoprotein that possesses a variety of functions, such as antibacterial, anti-inflammatory, antitumor, and intestinal health promotion. However, its application was restricted by its instability and poor gelation property. Recently, an increasing number of studies have focused on the synergistic effects of LF to broaden its application in the fields of functional food, nutritional supplements, and health care. LF can form complexes with other substances or be modified to enhance its stability and functionality. Additionally, the charge characteristics and cage-like structure of LF enable it to act as a carrier to encapsulate and protect functional ingredients. Furthermore, due to its broad range of receptors, LF can serve as a targeted delivery material for the precise delivery of functional ingredients. New insights into future research trends were also present, which are expected to further expand the utility of LF.