评估口服锌补充剂对牙周炎患者唾液MMP-8水平的影响：一项随机、双盲、安慰剂对照研究

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-03-11 DOI:10.1016/j.jobcr.2025.02.013

Vishakha Gupta , Pavitra Rastogi , Sadhna Ajay , Nand Lal , Umesh Pratap Verma , Rameshwari Singhal , Anjani Kumar Pathak , Nitu Nigam , Paridhi Rastogi

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引用次数: 0

摘要

背景与目的锌是人体必需的微量营养素，对维持口腔健康起着至关重要的作用。牙周炎是一种广泛的口腔疾病，其特征是牙龈和周围组织的炎症和破坏。本研究的目的是通过评估口服锌补充剂对临床参数和唾液MMP-8水平的影响，来评估口服锌补充剂作为牙周炎刮治和牙根刨治的辅助治疗效果。方法选取印度某三级医院牙周病科门诊的42例患者进行研究。研究对象分为两组：1组和2组各21例中重度牙周炎患者。组1给予口服补锌及洗牙刨根（SRP）治疗，组2给予安慰剂片及SRP治疗，疗程1个月。在基线和治疗后1个月，评估几项牙周参数，包括乳头出血指数（BI）、牙龈指数（GI）、探测袋深度（PPD）和临床附着水平（CAL）。在基线和1个月时收集约3ml未受刺激的全唾液，用ELISA法测定MMP-8。结果数据采用SPSS 26进行统计分析。所有临床参数和唾液中MMP-8水平在基线时具有可比性。各组治疗1个月后，各临床指标及唾液MMP-8水平差异均有统计学意义，1组（锌+ SRP） GI、PPD、CAL显著降低(p <；与2组（安慰剂+ SRP）相比，BI和唾液MMP-8水平显著降低(p <；0.05)。结论中重度牙周炎患者口服补锌同时进行刮治和牙根刮治，与单独进行刮治和牙根刮治相比，其临床指标和唾液MMP-8水平均有较大的降低。锌对牙周炎的治疗有积极的作用，可以作为一种简单、经济、无害和有益的辅助治疗牙周炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

To evaluate the effect of oral zinc supplementation on salivary MMP-8 levels in periodontitis: A randomized, double-blind, placebo-controlled study

查看原文本刊更多论文

To evaluate the effect of oral zinc supplementation on salivary MMP-8 levels in periodontitis: A randomized, double-blind, placebo-controlled study

Background and objective

Zinc is an essential micronutrient that plays a crucial role in maintaining oral health. Periodontitis is a widespread oral disease characterized by inflammation and destruction of the gums and surrounding tissues. The objective of this study was to evaluate the effect of oral zinc supplementation as an adjunct to scaling and root planing in the treatment of periodontitis by evaluating its effects on clinical parameters and salivary MMP-8 level.

Methods

42 patients were enrolled in the study from the periodontology OPD of a tertiary care hospital in India. The subjects were divided into two groups: group 1 and group 2 consisting of 21 patients each of moderate to severe periodontitis. Group 1 was given oral zinc supplementation along with scaling and root planing (SRP) and group 2 was given placebo tablet along with SRP for 1 month. Several periodontal parameters were assessed, including Papillary bleeding Index (BI), Gingival index (GI), Probing pocket depth (PPD) and Clinical attachment level (CAL) at baseline as well as at 1 month post treatment. Around 3 ml of whole unstimulated saliva was collected for MMP-8 estimation by ELISA method at baseline as well as at 1 month.

Results

The data was analyzed using SPSS version 26. All clinical parameters and MMP-8 level in saliva were comparable at baseline. 1 month after respective treatment modalities were performed in each group, it was found that all clinical parameters and salivary MMP-8 level showed significant differences with group 1 (zinc + SRP) showing highly significant decrease in GI, PPD and CAL (p < 0.01) and significant decrease in BI and salivary MMP-8 level when compared to group 2 (placebo + SRP) (p < 0.05).

Conclusion

When compared with scaling and root planing alone, the administration of oral zinc supplementation along with scaling and root planing showed greater reduction in clinical parameters and salivary MMP-8 levels in patients with moderate to severe periodontitis. Zinc has a positive effect in management of periodontitis and can serve as an easy, cost effective, harmless and beneficial adjunct in treatment of periodontitis.

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.